Here's my Super Smash Bros. franchise experience:
Super Mario: Yes, most main series games and many spin-offs
Donkey Kong: Yes, many main series games
The Legend of Zelda: Yes, nearly all games
Metroid: Yes, about 4 games (Other M was my first)
Yoshi: Played a bit of Yoshi's Island: Super Mario Advance 3 and Yoshi's New Island
Kirby: Yes, most main series games and some spin-offs
Star Fox: Yes, Star Fox 64 3D
Pokémon: Yes, all main series games and many spin-offs
F-Zero: Played a bit of SNES F-Zero and F-Zero Maximum Velocity
EarthBound/MOTHER: Played a bit of EarthBound and a bit of MOTHER 3 (fan translation)
Ice Climber: Yes
Fire Emblem: Yes, Fire Emblem Awakening and a bit of Fire Emblem: The Sacred Stones
Game & Watch: Yes, some Game & Watch Gallery and Game & Watch Collection games, and I own a Game & Watch: Ball reproduction
Kid Icarus: Yes, Kid Icarus: Uprising and a bit of 3D Classics: Kid Icarus and Kid Icarus: Of Myths and Monsters
Wario: Yes, most WarioWare games and a bit of some Wario Land games
Metal Gear: Played a bit of Metal Gear Solid: Snake Eater 3D
Pikmin: Yes, all 3 games
Sonic: Yes, most main series games and many spin-offs
R.O.B.: No, unless Mario Kart DS counts, lol
Animal Crossing: Yes, all games
Mega Man: Yes, Mega Man, and a bit of some other NES, GB, and SNES Mega Man games
Wii Fit: Yes, all 3 games
Punch-Out!!: Yes, Punch-Out!! Featuring Mr. Dream
Mii: Yes, all Wii Sports, Wii Play, Wii Music, Wii Party, etc. games, plus StreetPass Mii Plaza, Tomodachi Life, etc.
Pac-Man: Yes, Pac-Man, Pac-Man Championship Edition, Pac-Man Tilt, Pac-Man Vs., and Pac-Man Battle Royal
Xenoblade Chronicles: Yes (very recently!)
Duck Hunt: Yes
So the only franchise featured in Smash Bros. with a playable character that I've never actually played is the R.O.B. series. I actually own a copy of Gyromite for NES, but I have no R.O.B., sadly... One day, maybe.