Here's a sample layout for Mass Effect 2 in Xpadder:
Controls are:
Left stick - movement
Right stick - camera
Right trigger - Fire
Left trigger - Zoom
Left trigger hold + right stick - camera in pause in combat mode
Right bumper - toggle pause in combat mode (like holding Space but You don't need to hold it, just press)
Left bumper - run
A - action
B - draw weapon, cancel
X - first aid
Y - grenade
(similar to menu design
D-Pad right - inventory
D-Pad up - Squad
D-Pad left - Map
D-Pad down - Journal
Back - Menu (Esc)
Start - Toggle between Mako steering and normal steering
Mako steering is like in racing games + bumpers - weapons, A - jump