http://www.gaslamp.org/
From where you are, it's just down the 163. The 163 "dead ends" once you get past the 8 and turns into a surface street that will get you in the vicinity of the Gaslamp District. There are a ton of nice restaurants and nightclubs down there, though I'm not sure about what's going on Wednesday nights. Check out
http://entertainment.signonsandiego.com/ to see if they have any event listings at the clubs down there.
If you're looking for strip clubs or THAT kind of entertainment, you're probably out of luck. Most of those places are in Clairemont Mesa...it's funny, I was just having this discussion the other day with my sister, who works in urban planning for the county. From where you are, it would be north on the 163, then west on the 52. After that point, you'd have to start looking for them on the side of the highway...I've never been to any of 'em, so I dunno how to get there, though I've seen them while driving home on many occasions.
Have fun!