I know there were windows front ends, and I played around with Glide and D3D versions of Blood, so I'm going to assume that something has cropped up somewhere, though I've not seen it.
Doesn't work on mine at all in XP. It tries to go in and then just crashes back to desktop. With the program that Schafer found, I can now play it again
I <3 Duke3D. I can't wait until JonoF's port includes a decent in-game multiplayer matchmaker of some kind.
Even further, I can't wait until a) I can figure out how to implement MD2s, and b) The e-duke Con enhancements are added so I can actually change weapon properties.