Scientists to make 'Stuart Little' mouse with the brain of a human
By James Langton in New York
(Filed: 06/03/2005)
It will look like any ordinary mouse, but for America's scientists a tiny animal threatens to ignite a profound ethical dilemma.
In one of the most controversial scientific projects ever conceived, a group of university researchers in California's Silicon Valley is preparing to create a mouse whose brain will be composed entirely of human cells.
The group is waiting for a key American government-sponsored report, due this month, that will decide just how much science can blur the distinction between man and beast.
Last week, however, the university's ethics committee approved the research, under certain conditions. Prof Henry Greely, the head of the committee, said: "If the mouse shows human-like behaviours, like improved memory or problem-solving, it's time to stop."
President George W Bush halted government-funded research during his first term of office but several states, including California, have since passed laws that allow support for stem cell projects from local taxes.
At hearings in Washington last October, Prof Weissman argued strongly against a ban on "chimera mice". He believes that the mice would behave like any others, but said that he would monitor the experiment closely and destroy them at the slightest suggestion of human-like brain patterns.
Should two such "chimera mice" mate, it could lead to the nightmarish scenario of a human embryo trapped in a mouse's womb. William Cheshire, a neurology professor from the Mayo Clinic in Florida and a Christian activist, has called for a ban on any research that destroys a human embryo to create a new organism.
"We must be careful not to violate the integrity of humanity or of animal life,'' he said. "Research projects that create human-animal chimeras risk disturbing fragile ecosystems, endanger health and affront species integrity.''
In a recent article for the conservative Weekly Standard magazine, Wesley Smith, a consultant for the Centre for Bioethics and Culture warned that "biotechnology is becoming dangerously close to raging out of control''.
He wrote: "Scientists are engaging in increasingly macabre experiments that threaten to mutate nature and the human condition."
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