I can't believe this actually got greenlit, and not as a straight-to-video release or TV movie. Maybe this would work as a comedy...
http://www.darkhorizons.com/news04/040628d.php
http://www.darkhorizons.com/news04/040628d.php
"Ronny Yu is on board to direct the thriller "Snakes on a Plane" for New Line Cinema. Don Granger is producing. "Snakes" centers on a ruthless assassin who unleashes a crate full of lethal snakes aboard a packed passenger jet over the Pacific Ocean in order to eliminate a witness in protective custody. The rookie pilot and frightened passengers must band together to survive..."