Allow me to copy this post for my experience:
Mario: I've played just about every game in the Mario franchise, with the exception of the Mario Party games.
Yoshi: I've completed both SMW2 and New Island, and I've only played a small amount of Yoshi's Story. Never had an N64 growing up. :|
Wario: Played every single Wario Land title, and I've 100% completed every single WarioWare title.
Donkey Kong: Donkey Kong GB is one of my favorite GameBoy games ever, and I managed to 100% complete it too. I've also completed DKC, but never the other two DKC titles.
Game and Watch: I own all 4 volumes of Game & Watch Gallery, and even the Club Nintendo-exclusive Game & Watch Collection for the DS.
Zelda: I have played a few Zelda titles, but never to completion. LBW is pretty good though.
Metroid: I was never a huge fan of Metroid.
Kid Icarus: I have played both the original NES game and Uprising. Honestly, I think Uprising is one of the best games on the 3DS, if not EVER.
Fire Emblem: Never. I do hope to pick up Awakening in the near future though.
Kirby: I've completed both Kirby's Adventure and Kirby's Dream Land. I'm probably gonna be picking up Triple Deluxe the same day that I also pick up my copy of Smash for 3DS.
Little Mac: Played both the original and Wii version. I could never beat Mike Tyson/Mr. Dream in the NES version, nor could I beat Donkey Kong in the Wii version. Both are hard as fuck, yo.
Star Fox: I've played a good chunk of Star Fox 64 before losing interest. I am eager to give it another go if I ever pick up the 3DS port.
Pokemon: I've played Pokemon through Gen 1 to Gen 2. Then I took a break until X/Y was released. I'm currently chugging through Y, so... Yeah.
Duck Hunt: I had the original SMB/DH NES cartridge. I played the shit out of Duck Hunt until my family upgraded our TVs to HD, of which then the Zapper stopped working. :|
ROB: Never owned one, but I have heard about it before Brawl was released, thanks to WarioWare.
Mother: Eh... I could never get into the Mother series. I tried playing Mother 3, but I lost interest an hour into the story.
F-Zero: I've played the GBA version and GX on the GameCube. I demand a sequel, Nintendo/Sega! Make it happen!
Animal Crossing: I've clocked almost 200+ hours on New Leaf. Send help.
Pikmin: I've played Pikmin 1, but never Pikmin 2. Eh.
Wii Fit: I do own this game, but I own it just as a collectable item. I barely use it for exercising.
Dr. Mario: I've played the NES and Japan-only GameCube port of Dr. Mario 64. It's alright.
Xenoblade: Watching an LP of it right now. I'm really feeling it. And I'm feeling that I should give it a shot in the near future.
Pac-Man: Pac-Mania is one of my favorite arcade titles of all time, and Pac-Man World is one of my favorite PlayStation titles of all time. Enough said. Wakka Wakka.
Mega Man: I've completed Mega Man 2, but that's about it. Those games are way too hard, man!
Sonic: Sonic is one of my favorite game franchises of all time, and I've played just about every single title starring the Blue Blur; with the exception of Lost World since I don't own a Wii U. The only two Sonic games I've never completed are '06 since it's god-awful and Lost World 3DS since it cranks up the difficulty to "Oh God Why?!"-tier after World 3.
Metal Gear Solid: Never.
Ice Climbers: I've played the NES version for all of five minutes. I'm assuming it's more fun when two players are involved.