I've run this weeks six times already (group was going for rat king, we were missing it by 1-2 mins a few times and then ran once for clan engram) and its a lot easier than last weeks. There are three areas where you want to sorta clear enemies first and then touch the first circle thing, you have about a minute once you touch the circle before they despawn but the ~10 or so that spawn EACH give you +30 seconds, so if you do it right thats an additional 9 mins for all 30 or so (3 sets of 10 each).
At the boss as well the adds despawn when he moves to the next phase, so don't even bother DPSIng adds just burn the boss with the right elemental and heavies to move between phases, we killed him in under a minute each time including all the level timing bullshit which wastes a lot of time. Save your supers and circles for the bottom and you can kill him in a few seconds from 50% health.
That said I'm not really not a fan of the nightfall mechanisms, at least the timing thing. Its great for prestige maybe but shouldn't be there for regular NF. I wonder how it all works with guided games, is there a timer? What kind of drops do you get for guided?