Becoming a Ghoul in Fallout 76 is more than just an aesthetic change – it will significantly alter gameplay and your character build. As soon as you hit level 50, you will unlock a quest that will start you down the road of transforming into a Ghoul. Once the change is complete, you will unlock new Ghoul-specific perks and abilities. You'll be able to harness radiation to give you additional powers and buffs, and certain factions will react to you differently than if you were a human.