I'm glad it bombed as hard as it did. Maybe next time publishers will think twice before "modernizing" (ie shooterizing) classic PC games.
I don't think it's inherently wrong to investigate genre shifts within a universe; in principle, I'm fine with the idea of FPSes set within the Syndicate or X-Com (or, for that matter, Shadowrun) universes; I think the Metroid universe might just lend itself to a nice survival horror adventure, and I could see the merit in a Resident Evil squad-based strategy game.
I don't think devs should be scared to do that despite the reactions here; these universes are more adaptable than the genres that birthed them, and they shouldn't be shackled to just one genre.
...that said, if you do that, mention "It's set within the Syndicate universe" casually, in passing. Don't start promoting it as "a new Syndicate game". Gamers will generally associate titles with *genres*, not universes.
...
that said, though, that does require you to keep a tight lid on leaks and exert very careful control of how the news is delivered; a leak with insufficient information will mutate and become dangerous *very* quickly, and it's very easy for your intent to get lost and peoples' expectations become impossible to meet.
In this specific example, I honestly don't recall: in what context did we *first* hear that 'a new Syndicate game' was on the way?