Alright, let's just calm down now...LOL
What can we expect?
Game & Wario: Brief Mention, maybe couple more game descriptions.
New Super Luigi U: Brief Mention, new trailer and rediscuss release setup
Pikmin 3: Challenge and Multiplayer modes (No Online)
The Wonderful 101: Gameplay and story discussion, Iwata Asks Post-ND
Bayonetta 2: Trailer (2014 release)
The Legend of Zelda: Wind Waker HD: Upgrade graphics, Master Quest or *1* New Dungeon at most
New Wii U Zelda: Just a mention, no new details whatsoever
New 3D Mario: Full Unveiling, Logo, Relative Release, Footage, Iwata Asks Post-ND
New Mario Kart: Full Unveiling, Logo, Relative Release, Footage, Iwata Asks Post-ND
Wii Fit U: Remention, Relative Release, New Footage, Fall 2013
Wii Party U: Rename?, More Footage, More Overview, Fall 2013
X: Official Rename, More Footage, 2014 Release, JPN-Only Iwata Asks Post-ND
Yoshi Yarn: Official Rename, More Footage, Early 2014 Release, Iwata Asks Post-ND
Retro's New Game (if not Mario Kart): Full Unveiling, Logo, Relative Release, Footage
Super Smash Bros.: Unveiling, Logo, No release date, Reveals 4 characters
Little room for more, there, especially if third parties arrive. Heck, they might even drop some of those in favor of filling third-party info (WB, Sega, SMT X FE). Also, note no mention of the Summer Update or VC. Those will be saved for post-E3, I feel.
Also, at the end, they will mention a 3DS ND scheduled for later in the week, with.
Mario & Luigi: Dream Team: New Footage, More Discussion, Maybe Iwata Asks
Mario Golf: World Tour: New Footage, More Discussion, Release Date Confirm
Pokemon X & Y (could be given its own ND during roundtable): New Footage, Info
The Legend of Zelda: LTTP2: Official Rename, More Footage, December, Iwata Asks Post-ND
Mario Party 3D: New Footage, More Discussion, Early 2014 Release
Yoshi's Island: Official Rename, More Footage, 2014 Release
Super Smash Bros.: Unveiling, Different Logo from U, details on connection
New Kirby Title: I'd say it's about time to at least announce a new Kirby 3DS game.
It would be crazy if Friend Collection or Jam with the Band was confirmed for US, but I have my doubts.
Anyways, there is room for bigger or completely out-of-the-blue announcements, but I'm not holding my breath, especially given the above.