I'm not so sure that Highguard is supposed to be aimed mainly at women, but if they were trying to do that, that seems like some bad judgment lol. I mean, it's just common sense that these multiplayer shooter games are mostly played by men.
If you try to appeal to everyone all at once too much (which is what I think happened here, although it's a bit more complicated than that.), then you end up with a boring, safe product that appeals to no one, and if you try to appeal to an audience that isn't interested, you won't sell any copies either, so I think that you're right that these shooter games probably should be trying harder to appeal to men.