I'm currently in the middle of my first viewing of Legend of the Galactic Heroes and, with some editing and the proper budget, it would make a fantastic american tv series.
Plot-wise is very similar to GoT (although without boobs) so we know there's an audience for it, but LotGH's concepts are much thicker than it, so they should find a way to make it more understandable (i swear if you don't pay attention for a couple of seconds, you could miss whats going on in the following scenes) but without losing it's complexity.
The plot is already self contained in arcs that have clear beginnings and endings, that would make it easy to make seasons out of it. Around 20 would be ideal.
It really depends on the budget though, considering some battles are just stills of spaceships and commander's war tables, but others are much more complex and detailed.
It's also one of those anime that would greatly benefit from being represented by western actors, actually of all races.