I'm taking a strict definition of "one and done" here, as in, a game that was released on one platform, was not part of a pre-existing franchise or licensed property, never got any sequels, remakes, or remasters, and has never been re-released, not even as part of a retro compilation or on a DD service.
Any suggestions for contenders?
EDIT: Okay, I've gone through the North American NES, Genesis, SNES, PS1, N64, PS2, GameCube, and Xbox libraries and compiled all the games that satisfy the requirements. These lists should be complete. I have ranked them according to their number of GameFAQs user ratings, which is a pretty good indicator of notoriety, if not quality.
NES: 150 games out of 758
The Adventures of Bayou Billy- 231
Abadox- 176
Dr. Jekyll and Mr. Hyde- 162
Gyromite- 136
Deadly Towers- 135
Metal Storm- 133
Monster Party- 131
8 Eyes- 127
Clash at Demonhead- 122
Cobra Triangle- 121
Shatterhand*- 116 [JP version is based on Super Rescue Solbrain]
Color a Dinosaur- 111
Kabuki Quantum Fighter- 111
Anticipation- 106
Wrath of the Black Manta- 101
Xexyz- 97
Demon Sword- 95
Code Name: Viper- 94
Vice: Project Doom- 94
Adventures of Dino Riki- 93
Air Fortress- 93
Little Samson- 91
The Magic of Scheherazade- 89
Swords and Serpents- 80
Amagon-77
Kickmaster- 76
Gun Nac- 74
Base Wars- 73
Conquest of the Crystal Palace- 73
Werewolf: The Last Warrior- 71
Othello*- 67 [not clear if this is based on a licensed version of the game]
Time Lord- 66
Iron Tank*- 61 [sort-of sequel to TNK III]
Tecmo World Wrestling- 60
Low G Man- 59
Nightshade- 55
Adventures of Tom Sawyer- 54
Totally Rad- 54
Dynowarz: Destruction of Sponylus- 52
Taboo: The Sixth Sense- 52
Arkista’s Ring- 51
Ninja Crusaders- 48
Panic Restaurant- 48
Bad News Baseball*- 47
The Adventures of Rad Gravity- 43
To the Earth- 43
Sword Master- 42 [quasi-sequel to Castle of Dragon]
Pinball Quest- 41
Kid Kool*- 40
Star Voyager- 40
Dash Galaxy in the Alien Asylum- 38
Quattro Adventure*- 38 [only 1 of the 4 games qualifies]
Battle Tank- 37
Dragon Fighter- 37
Frankenstein: The Monster Returns- 37
Isolated Warrior- 37
Vegas Dream- 37
Desert Commander- 35
Eliminator Boat Duel- 35
Bible Buffet- 34
Ghoul School- 34
Day Dreamin’ Davey- 33
Ghost Lion- 33
Zombie Nation- 33
Dungeon Magic: Sword of the Elements- 32
Wurm: Journey to the Center of the Earth- 32
Stealth ATF- 31
Faria- 30
Chubby Cherub*- 28 [JP version is based on Q-taro]
Digger T. Rock- 28
Master Chu and the Drunkard Hu- 28
Metal Mech: Man & Machine- 28
Super Glove Ball- 28
The King of Kings: The Early Years- 27
Circus Caper- 26
Dusty Diamond’s All-Star Softball- 26
The Ultimate Stuntman- 26
Galaxy 5000: Racing in the 51st Century- 25
Stack-Up- 25
Formula One: Built to Win- 24
Krazy Kreatures- 24
Destination Earthstar- 23
Phantom Fighter*- 23 [JP version is based on the movie Mr. Vampire]
Magician- 22
Treasure Master- 22
Defenders of Dynatron City- 21
Little League Baseball: Championship Series*- 21 [sort-of spinoff to Baseball Stars]
All-Pro Basketball- 20
Monster Truck Rally- 20
Starship Hector*- 20
Baby Boomer- 19
Bandai Golf: Challenge Pebble Beach*- 19 [not sure if this game is licensed or not]
Space Shuttle Project- 19
Ultimate Air Combat- 19
Bee 52- 18
Capcom’s Gold Medal Challenge ’92- 18
Cowboy Kid- 18
Laser Invasion-18
Sqoon*- 18 [Received a quasi-sequel, In the Hunt, on the Neo Geo]
Tagin’ Dragon- 18
Crystal Mines- 17
Dudes with Attitude- 17
F-117A Stealth Fighter- 17
Peek A Boo Poker- 17
Race America*- 17 [European version is a Chevrolet-licensed game]
Big Nose Freaks Out- 16
Orb 3D- 16
Deathbots- 15
F-15 City War- 15
Heavy Shreddin’- 15
Mission Cobra- 15
Pyramid- 15
Magic Darts- 14
Raid 2020- 14
Shooting Range- 14
Blackjack- 13
Challenge of the Dragon- 13
King Neptune’s Adventure- 13
Puzzle- 13
Videomation- 13
Metal Fighter- 12
Operation Secret Storm- 12
Quattro Arcade*- 12 [only 2 of the 4 games qualify]
Silent Assault- 12
World Champ- 12
Castle of Deceit- 11
Death Race- 11
Galactic Crusader- 11
Motor City Patrol- 11
The Mutant Virus: Crisis in a Computer World- 11
Power Punch II- 11
Robodemons- 11
Rock ‘n Ball- 11
Break Time: The National Pool Tour- 10
Double Strike- 10
Secret Scout in the Temple of Demise- 10
Moon Ranger- 9
Solitaire- 9
Tiles of Fate- 9
Ultimate Basketball- 9
Golf Grand Slam- 7
P’radikus Conflict- 7
Short Order / Eggsplode!- 7
Stanley: The Search for Dr. Livingstone- 7
Stunt Kids- 7
Venice Beach Volleyball- 7
Rad Racket: Deluxe Tennis II- 5
Roundball 2-on-2 Challenge- 5
Shockwave- 5
Ultimate League Soccer- 5
Sega Genesis: 50 games out of 708
Crusader of Centy- 129
Alisia Dragoon- 122
Ranger X- 105
General Chaos- 104
Skitchin’*- 71 [sort-of spinoff of Road Rash]
Cyborg Justice- 67
Elemental Master- 67
Zero Tolerance- 62
Sub-Terrania- 61
Blades of Vengeance- 59
Gaiares- 59
Arrow Flash- 54
Jewel Master- 46
Awesome Possum- 36
Rolo to the Rescue- 34
F022 Interceptor- 30
Rings of Power- 28
Generations Lost- 27
Combat Cars- 26
Red Zone- 26
Traysia- 26
Fighting Masters- 25
Crystal’s Pony Tale- 24
Sorcerer’s Kingdom- 24
Tinhead- 24
Mystical Fighter- 22
Shove It! The Warehouse Game- 20
Whip Rush- 18
F-117 Night Storm- 17
Menacer 6-Game Cartridge- 17
Technoclash- 17
Beast Wrestler- 16
Bimini Run- 14
Gadget Twins- 14
Socket- 13
Death Duel- 12
Nightmare Circus- 12 [cartridge game in some places, Sega Channel-only in others; this variance may disqualify it]
Saint Sword- 12
Dino Land- 11
Shadow Blasters- 11
Trampoline Terror- 11
Ka-Ge-Ki: Fists of Steel- 9
Dashin’ Desperadoes*- 8 [Wikipedia claims it got a sequel on PS2, but I've found no info on it at all]
Earth Defense- 8
King Salmon: The Big Catch- 8
Quad Challenge- 8
Normy’s Beach Babe-O-Rama- 5
Mallet Legend’s Whac-A-Critter- 4
Pro Moves Soccer- 2
Funny World & Balloon Boy- 1
SNES: 77 games out of 720
Illusion of Gaia*- 944 [arguably affiliated with Soul Blazer/Terranigma/Granstream Saga]
Secret of Evermore*- 854 [marketed as a sort-of sequel to Secret of Mana]
Soul Blazer*- 443 [arguably affiliated with Illusion of Gaia/Terranigma/Granstream Saga]
The 7th Saga*- 310 [Mystic Ark is a quasi-sequel to this game]
Uniracers- 214
Stunt Race FX- 202
Robotrek- 180
Brain Lord- 160
Arcana- 134
Super Scope 6- 134
Skyblazer- 107
Metal Warriors*- 99 [Marketed as a sort-of follow-up to Cybernator]
Plok- 98
Tecmo Secret of the Stars- 96
Hagane- 82
Claymates*- 79 [Clayfighter was a sort-of follow-up to this game]
Lester the Unlikely- 71
Young Merlin- 59
King Arthur’s World- 54
Hyperzone- 52
Run Saber- 50
X-Kaliber 2097- 48
Ardy Lightfoot- 47
Xardion- 45
Nosferatu- 43
Tin Star- 39
Smart Ball- 36
Tuff E Nuff- 35
Vortex- 33
D-Force- 32
Big Sky Trooper- 30
Dirt Trax FX- 29
ASP: Air Strike Patrol- 28
Battle Cars- 28
Captain Novolin*- 27 [arguably affiliated with Rex Ronan/Bronky/Packy & Marlon]
Rocky Rodent- 26
Super Pinball: Behind the Mask*- 26
Extra Innings- 25
Firestriker- 25
HAL’s Hole in One Golf*- 25 [JP version features Jumbo Ozaki]
Musya- 25
Cacoma Knight in Bizyland- 24
Harley’s Humongous Adventure- 24
Time Slip- 19
Imperium- 18
Bazooka Blitzkrieg- 17
Cyber Spin*- 16 [JP version is based on Future GPX Cyber Formula]
Power Piggs of the Dark Age- 16
Dig & Spike Volleyball- 15
Pieces- 15
World Soccer ’94: Road to Glory- 15
Carrier Aces- 14
Doomsday Warrior- 14
Frantic Flea- 14
Hammerlock Wrestling*- 14 [JP version features Genichiro Tenryu]
Incantation- 14
Skuljagger: Revolt of the Westicans- 13
RPM Racing*- 12
Shien’s Revenge- 12
X-Zone- 12
Battle Grand Prix- 11
Realm- 11
Air Cavalry- 10
Metal Morph- 10
Mohawk and Headphone Jack- 10
Bronkie the Bronichiasaurus- 9 [arguably affiliated with Packy & Marlon/Rex Ronan/Captain Novolin]
Full Throttle All-America Racing- 9
Rex Ronan: Experimental Surgeon*- 9 [arguably affiliated with Packy & Marlon/Bronky/Captain Novolin]
Super Slap Shot*- 9 [apparently endorsed by Gordie Howe, not clear if it actually features him though]
International Tennis Tour- 8
Dream TV- 7
Space Football- 6
Mecarobot Golf*- 5 [JP version features Nobuo Serizawa
Street Hockey ’95- 5
Packy & Marlon*- 4 [arguably affiliated with Rex Ronan/Bronky/Captain Novolin]
Football Fury- 3
TKO Super Championship Boxing*- 5 [JP version features Jiro Matsushima on the cover]
PS1: 102 games out of 1243
Thousand Arms- 228
Beyond the Beyond- 204
Evil Zone- 128
The Granstream Saga- 128 [sort-of-related to Soul Blazer/Illusion of Gaia/Terranigma]
Omega Boost- 117
Wild 9- 107
Shadow Madness- 106
Apocalypse- 103 [uses Bruce Willis's voice and likeness and so might be considered a licensed game]
Eternal Eyes- 91
Akuji the Heartless- 65
Incredible Crisis- 65 [may have been released twice in Europe; info is unclear]
Tail Concerto- 63 [Solatorobo on the DS is a sort-of-sequel to this game]
Blasto- 59
Ninja: Shadow of Darkness- 55
Soul of the Samurai- 54
Rogue Trip: Vacation 2012- 52 [unofficial sequel to Twisted Metal 1/2]
The Unholy War- 51
Project Overkill- 49
Team Buddies- 47
Cardinal Syn- 46
Speed Punks- 45
Monsterseed- 43
Covert Ops: Nuclear Dawn- 42
Disruptor- 42
T'ai Fu: Wrath of the Tiger- 42
Treasures of the Deep- 41
Tiny Tank- 39
Countdown Vampires- 38
Elemental Gearbolt- 38
Rascal- 33
Grind Session- 32 [some skaters are licensed]
No One Can Stop Mr. Domino- 32
Monkey Hero- 30
Spider: The Video Game- 30
Kensei: Sacred Fist- 28
Project Horned Owl- 28
Trap Gunner- 28
Kingsley's Adventure- 27
Mort the Chicken- 23
Assault: Retribution- 21
One Piece Mansion- 20
Auto Destruct- 19
Power Moves Pro Wrestling- 19 [sort-of spinoff of Toukon Retsuden]
Broken Helix- 16
Boombots- 15
Circuit Breakers- 15
Eagle One: Harrier Attack- 15
Space Griffon VF-9- 15
NGEN Racing- 14
Running Wild- 14
Cyberspeed- 13
Juggernaut- 13
No Fear Downhill Mountain Biking- 13
Steel Reign- 13
Dead Ball Zone- 12
Grudge Warriors- 12
Killing Zone- 12
Invasion from Beyond- 11
Nanotek Warrior- 11
RC Revenge- 11 [sort-of-spinoff of Re-Volt]
R/C Stunt Copter- 11
Steel Harbinger- 11
Bogey Dead 6- 10
Punky Skunk- 10
Tennis- 10
All Star Racing- 9
Psybadek- 9
RC de Go!- 9 [sort-of related to RC Revenge/Re-Volt]
Big Air- 8 [contains licensed snowboarding gear]
Big Strike Bowling- 8
Burning Road- 8
Floating Runner- 8
Pitball- 8
Rush Hour- 8
Saltwater Sportfishing- 8
Family Game Pack- 7
Professional Underground League of Pain- 7
American Pool- 6
Blast Radius- 6
Bug Riders- 6
Dare Devil Derby 3D- 6
Starwinder- 6
Surf Riders- 6
Vanark- 6
Patriotic Pinball- 5
Phix: The Adventure- 5
VMX Racing- 5
The Bombing Islands- 4 [almost the same game as Charlie Blast's Territory on N64]
Super Shot Soccer- 4
Eggs of Steel- 3
Freestyle Boardin' '99- 3
Rushdown- 3
Trick'N Snowboarder- 3 [arcade predecessor?]
ATV Mania- 2
The Final Round- 2
Power Serve 3D Tennis- 2
Burstrick: Wakeboarding- 1
Easter Bunny's Big Day- 1
Family Card Game Fun Pack- 1
Slots- 0
Tecmo World Golf- 0
World Cup Golf- 0 [licensed game?]
N64: 23 games out of 296
Jet Force Gemini- 691
Blast Corps- 425
Mischief Makers- 394
Body Harvest- 190
Hybrid Heaven- 146
Buck Bumble- 101
Rocket: Robot on Wheels- 97
Iggy's Reckin' Balls- 90
Aerogauge- 54
MRC: Multi-Racing Championship- 44
Deadly Arts- 42
Chopper Attack- 35
World Driver Championship- 33
Knife Edge: Nose Gunner- 31
Dual Heroes- 30
Virtual Chess 64- 30
GT 64: Championship Edition- 27 [may be a licensed game]
Charlie Blast's Territory- 20 [re-skinned version of The Bombing Islands on PS1]
Milo's Astro Lanes- 19
Twisted Edge Extreme Snowboarding- 19
Bassmasters 2000- 15
Stunt Racer 64- 14
Big Mountain 2000- 10
PS2: 90 games out of 1831
Radiata Stories- 906
The Bouncer- 472
Okage: Shadow King- 253
Shadow of Rome- 218
Rule of Rose- 209
Eternal Poison- 184
Ephemeral Fantasia- 169
Extermination- 142
Urban Reign- 124
Eternal Ring- 114
Bujingai: The Forsaken City- 113
Dog's Life- 102
Rise to Honor- 101 [features voice and likeness of Jet Li]
Ghosthunter- 97
Tourist Trophy- 94 [licensed vehicles]
Crimson Tears- 88
Kuon- 79
Cold Winter- 78
Downhill Domination- 75
Kya: Dark Lineage- 75
Samurai Western- 72
EOE: Eve of Extinction- 70
RAD: Robot Alchemic Drive- 69
Nanobreaker- 64
Skygunner- 64 [sequel on PC?]
Kinetica- 57
Haven: Call of the King- 54
Tsugunai: Atonement- 54
S.L.A.I.: Steel Lancer Arena International- 51 [sequel to Phantom Crash?]
Enthusia Professional Racing- 50
Airblade- 48
Stretch Panic- 48 [released by two different publishers in Europe]
Rumble Racing- 46 [unofficial sequel to NASCAR Rumble]
Sky Odyssey- 44
Spy Fiction- 41
The Legend of Alon D'ar- 39
Lifeline- 39 [two SKUs released in Japan]
Legion: The Legend of Excalibur- 33
Under the Skin- 31
DT Racer- 30
Dark Angel: Vampire Apocalypse- 29
X-Squad- 29
Dragon Rage- 28
Herdy Gerdy- 28
The Adventures of Darwin- 26 [part of the "Simple 2000" label in Japan]
HSX Hypersonic Xtreme- 25
Dance Factory- 24 [licensed music]
Driving Emotion Type-S- 24 [contains licensed cars]
Brave: The Search for Spirit Dancer- 21
Endgame- 21 [released twice in Europe]
Godai Elemental Force- 21
Summer Heat Beach Volleyball- 21
Super Trucks Racing- 21 [contains licensed trucks]
Firefighter F.D. 18- 20
Fugitive Hunter: War on Terror- 16
Yanya Caballista: City Skater- 16
Dropship: United Peace Force- 15
Music Maker- 15
Shox- 15 [contains licensed cars]
Flipnic: Ultimate Pinball- 14
Motor Mayhem- 14
Sub Rebellion- 13
Swing Away Golf- 13 [Disney Golf is sort-of a sequel to this game]
eJay Clubworld- 12 [contains licensed clubs]
Pryzm Chapter One: The Dark Unicorn- 12
Surfing H3O- 12
Wild Wild Racing- 12
City Crisis- 11
My Street- 11
RTX Red Rock- 10
Fisherman's Bass Club- 9 [sort-of sequel to Bass Hunt]
Hidden Invasion- 9
Jet X2O- 9
Wave Rally- 8
Real Pool- 7
Eagle Eye Golf- 6
Iridium Runners- 6
MX Rider- 6 [contains licensed tracks]
Bass Strike- 5
Flow: Urban Dance Uprising- 5
Get On Da Mic- 5 [licensed soundtrack]
Unison: Rebels of Rhythm & Dance- 5 [contains licensed music]
Global Touring Challenge: Africa- 4 [contains licensed cars]
Riding Spirits- 4 [contains licensed motorcycles]
Women's Volleyball Championship- 4 [Japanese version carries FIVP license]
World Championship Paintball- 4
Short Track Racing: Trading Paint- 3
Fisherman's Challenge- 2
Lowrider- 2
Karaoke Party- 0
Xbox: 38 games out of 891
Brute Force- 135
Breakdown- 131
Phantom Dust- 127
Gunvalkyrie- 115
Phantom Crash- 62 [SLAI for PS2 is sort-of a sequel to this game]
Voodoo Vince- 60
Kung Fu Chaos -59
Azurik- 48
Tao Feng: Fist of the Lotus- 46 [pretty much an unofficial Mortal Kombat game]
Quantum Redshift- 41
Whacked- 29
Deathrow- 25
Metal Dungeon- 21
Apex- 20
Mad Dash Racing- 20
Kakuto Chojin- 19
Black Stone: Magic & Steel- 18
Galleon- 17
New Legends- 17
Stake: Fortune Fighters- 16
Murakumo: Renegade Mech Pursuit- 15
Pulse Racer- 12
Chase: Hollywood Stunt Driver- 10
Kabuki Warriors- 10
Classified: The Sentinel Crisis- 9
Maximum Chase- 9
Sneakers- 8
Tork: Prehistoric Punk- 8
Carve- 7
Championship Bowling- 6
Iron Phoenix- 6
Pro Fishing Challenge- 6
Pro Cast Sports Fishing- 5 [part of the Lake Masters series?]
Knight's Apprentice: Memorick's Adventures- 4
Group S Challenge- 3 [features licensed cars]
Seablade- 3 [released as bundle with Outlaw Golf]
Toxic Grind- 2
Furious Karting- 1
Gamecube: 11 games out of 566
Eternal Darkness- 938
Geist- 233
PN 03- 212
Gotcha Force- 182
Cubivore- 111
Amazing Island- 110
Odama- 90
Go! Go! Hypergrind- 16
Tube Slider- 13
Swingerz Golf- 8
MC Groovz Dance Craze- 7 [contains licensed music]
Suggested games from other platforms (up to the end of page 11):
3D Dot Game Heroes (PS3)
Afrika (PS3)
Albion (DOS)
Arc Rise Fantasia (Wii)
Art Style: Pictobits (DS)
ASH: Archaic Sealed Heat (DS)
Astal (Saturn)
Battle Circuit (arcade)
Blade Force (3DO)
Bounty Hounds (PSP)
Bulk Slash (Saturn)
Buriki One (arcade)
Burning Rangers (Saturn)
Chromehounds (Xbox 360)
Code of Princess (3DS)
Contact (DS)
Cosmic Carnage (32X)
Crashday (Windows)
Dark Savior (Saturn) [borderline, arguable sequel to Landstalker]
The Dark Spire (DS)
Dark Wizard (Sega CD)
Dead Head Fred (PSP)
Deadly Creatures (Wii)
Deep Fear (Saturn)
Demon Front (arcade)
Demon's Souls (PS3) [borderline, Dark Souls is the sequel in all but name]
Disaster: Day of Crisis (Wii)
Dolphin Blue (arcade)
Drill Dozer (GBA)
Elemental Gimmick Gear (Dreamcast)
Elite Beat Agents (DS) [borderline, arguable spinoff of Ouendan]
Enemy Zero (Saturn) [borderline; features digital actress Laura, who previously starred in D]
Eschatos (Xbox 360)
Farjius no Jakoutei: Neo Metal Fantasy (PCE)
Fighting Layer (arcade)
Folklore (PS3)
Fragile Dreams (Wii)
Freedom Wars (Vita)
Gravity Rush (Vita)
Heavenly Sword (PS3)
Henry Hatsworth in the Puzzling Adventure (DS)
Hexyz Force (PSP)
Illbleed (Dreamcast)
Impossible Creatures (Windows) [had a few expansions, though]
Infinite Space (DS)
Jeanne d'Arc (PSP)
Kameo: Elements of Power (Xbox 360)
Kolibri (32X)
The Last Story (Wii)
LOL: Lack of Love (Dreamcast)
Lost Odyssey (Xbox 360)
Lunacy (Saturn)
Maboshi's Arcade (Wii)
Martial Masters (arcade)
Metal Fatigue (Windows)
Metal Head (32X)
Metropolis Street Racer (Dreamcast) [borderline, PGR was arguably a sequel]
Natatsu Kaze no Shima Monogatari (Saturn)
Night Slashers (arcade)
Nightmare in the Dark (arcade)
Ninja Baseball Bat Man (arcade)
Ninja Five-O (GBA)
Omega Five (Xbox 360)
One Way Heroics (Windows)
Opoona (Wii)
Osman (arcade) [borderline, unofficial sequel to Strider]
The Outfoxies (arcade)
Outlaws (Windows)
Penguin Land (SMS)
Prop Cycle (arcade)
Puppeteer (PS3)
Radiant Historia (DS)
Rain (PS3)
Red Dog: Superior Firepower (Dreamcast)
Rocket Jockey (Windows)
Shadow Complex (Xbox 360)
Soul Bubbles (DS)
Super Magnetic Neo (Dreamcast)
Teleroboxer (Virtual Boy)
Terra Phantastica (Saturn)
Too Human (Xbox 360)
Trinity (Z-Machine) [borderline, released on Z-Machine]
Wachenroder (Saturn)
Wake-up Club (Vita)
The Wonderful 101 (Wii U)
Yume Nikki (Windows)
Zack & Wiki (Wii)
ZHP: Unlosing Ranger vs. Darkdeath Evilman (PSP)
ZombiU (Wii U) [Note: some sources say it's a sequel to Zombi, but the devs said it's not]
Any suggestions for contenders?
EDIT: Okay, I've gone through the North American NES, Genesis, SNES, PS1, N64, PS2, GameCube, and Xbox libraries and compiled all the games that satisfy the requirements. These lists should be complete. I have ranked them according to their number of GameFAQs user ratings, which is a pretty good indicator of notoriety, if not quality.
NES: 150 games out of 758
The Adventures of Bayou Billy- 231
Abadox- 176
Dr. Jekyll and Mr. Hyde- 162
Gyromite- 136
Deadly Towers- 135
Metal Storm- 133
Monster Party- 131
8 Eyes- 127
Clash at Demonhead- 122
Cobra Triangle- 121
Shatterhand*- 116 [JP version is based on Super Rescue Solbrain]
Color a Dinosaur- 111
Kabuki Quantum Fighter- 111
Anticipation- 106
Wrath of the Black Manta- 101
Xexyz- 97
Demon Sword- 95
Code Name: Viper- 94
Vice: Project Doom- 94
Adventures of Dino Riki- 93
Air Fortress- 93
Little Samson- 91
The Magic of Scheherazade- 89
Swords and Serpents- 80
Amagon-77
Kickmaster- 76
Gun Nac- 74
Base Wars- 73
Conquest of the Crystal Palace- 73
Werewolf: The Last Warrior- 71
Othello*- 67 [not clear if this is based on a licensed version of the game]
Time Lord- 66
Iron Tank*- 61 [sort-of sequel to TNK III]
Tecmo World Wrestling- 60
Low G Man- 59
Nightshade- 55
Adventures of Tom Sawyer- 54
Totally Rad- 54
Dynowarz: Destruction of Sponylus- 52
Taboo: The Sixth Sense- 52
Arkista’s Ring- 51
Ninja Crusaders- 48
Panic Restaurant- 48
Bad News Baseball*- 47
The Adventures of Rad Gravity- 43
To the Earth- 43
Sword Master- 42 [quasi-sequel to Castle of Dragon]
Pinball Quest- 41
Kid Kool*- 40
Star Voyager- 40
Dash Galaxy in the Alien Asylum- 38
Quattro Adventure*- 38 [only 1 of the 4 games qualifies]
Battle Tank- 37
Dragon Fighter- 37
Frankenstein: The Monster Returns- 37
Isolated Warrior- 37
Vegas Dream- 37
Desert Commander- 35
Eliminator Boat Duel- 35
Bible Buffet- 34
Ghoul School- 34
Day Dreamin’ Davey- 33
Ghost Lion- 33
Zombie Nation- 33
Dungeon Magic: Sword of the Elements- 32
Wurm: Journey to the Center of the Earth- 32
Stealth ATF- 31
Faria- 30
Chubby Cherub*- 28 [JP version is based on Q-taro]
Digger T. Rock- 28
Master Chu and the Drunkard Hu- 28
Metal Mech: Man & Machine- 28
Super Glove Ball- 28
The King of Kings: The Early Years- 27
Circus Caper- 26
Dusty Diamond’s All-Star Softball- 26
The Ultimate Stuntman- 26
Galaxy 5000: Racing in the 51st Century- 25
Stack-Up- 25
Formula One: Built to Win- 24
Krazy Kreatures- 24
Destination Earthstar- 23
Phantom Fighter*- 23 [JP version is based on the movie Mr. Vampire]
Magician- 22
Treasure Master- 22
Defenders of Dynatron City- 21
Little League Baseball: Championship Series*- 21 [sort-of spinoff to Baseball Stars]
All-Pro Basketball- 20
Monster Truck Rally- 20
Starship Hector*- 20
Baby Boomer- 19
Bandai Golf: Challenge Pebble Beach*- 19 [not sure if this game is licensed or not]
Space Shuttle Project- 19
Ultimate Air Combat- 19
Bee 52- 18
Capcom’s Gold Medal Challenge ’92- 18
Cowboy Kid- 18
Laser Invasion-18
Sqoon*- 18 [Received a quasi-sequel, In the Hunt, on the Neo Geo]
Tagin’ Dragon- 18
Crystal Mines- 17
Dudes with Attitude- 17
F-117A Stealth Fighter- 17
Peek A Boo Poker- 17
Race America*- 17 [European version is a Chevrolet-licensed game]
Big Nose Freaks Out- 16
Orb 3D- 16
Deathbots- 15
F-15 City War- 15
Heavy Shreddin’- 15
Mission Cobra- 15
Pyramid- 15
Magic Darts- 14
Raid 2020- 14
Shooting Range- 14
Blackjack- 13
Challenge of the Dragon- 13
King Neptune’s Adventure- 13
Puzzle- 13
Videomation- 13
Metal Fighter- 12
Operation Secret Storm- 12
Quattro Arcade*- 12 [only 2 of the 4 games qualify]
Silent Assault- 12
World Champ- 12
Castle of Deceit- 11
Death Race- 11
Galactic Crusader- 11
Motor City Patrol- 11
The Mutant Virus: Crisis in a Computer World- 11
Power Punch II- 11
Robodemons- 11
Rock ‘n Ball- 11
Break Time: The National Pool Tour- 10
Double Strike- 10
Secret Scout in the Temple of Demise- 10
Moon Ranger- 9
Solitaire- 9
Tiles of Fate- 9
Ultimate Basketball- 9
Golf Grand Slam- 7
P’radikus Conflict- 7
Short Order / Eggsplode!- 7
Stanley: The Search for Dr. Livingstone- 7
Stunt Kids- 7
Venice Beach Volleyball- 7
Rad Racket: Deluxe Tennis II- 5
Roundball 2-on-2 Challenge- 5
Shockwave- 5
Ultimate League Soccer- 5
Sega Genesis: 50 games out of 708
Crusader of Centy- 129
Alisia Dragoon- 122
Ranger X- 105
General Chaos- 104
Skitchin’*- 71 [sort-of spinoff of Road Rash]
Cyborg Justice- 67
Elemental Master- 67
Zero Tolerance- 62
Sub-Terrania- 61
Blades of Vengeance- 59
Gaiares- 59
Arrow Flash- 54
Jewel Master- 46
Awesome Possum- 36
Rolo to the Rescue- 34
F022 Interceptor- 30
Rings of Power- 28
Generations Lost- 27
Combat Cars- 26
Red Zone- 26
Traysia- 26
Fighting Masters- 25
Crystal’s Pony Tale- 24
Sorcerer’s Kingdom- 24
Tinhead- 24
Mystical Fighter- 22
Shove It! The Warehouse Game- 20
Whip Rush- 18
F-117 Night Storm- 17
Menacer 6-Game Cartridge- 17
Technoclash- 17
Beast Wrestler- 16
Bimini Run- 14
Gadget Twins- 14
Socket- 13
Death Duel- 12
Nightmare Circus- 12 [cartridge game in some places, Sega Channel-only in others; this variance may disqualify it]
Saint Sword- 12
Dino Land- 11
Shadow Blasters- 11
Trampoline Terror- 11
Ka-Ge-Ki: Fists of Steel- 9
Dashin’ Desperadoes*- 8 [Wikipedia claims it got a sequel on PS2, but I've found no info on it at all]
Earth Defense- 8
King Salmon: The Big Catch- 8
Quad Challenge- 8
Normy’s Beach Babe-O-Rama- 5
Mallet Legend’s Whac-A-Critter- 4
Pro Moves Soccer- 2
Funny World & Balloon Boy- 1
SNES: 77 games out of 720
Illusion of Gaia*- 944 [arguably affiliated with Soul Blazer/Terranigma/Granstream Saga]
Secret of Evermore*- 854 [marketed as a sort-of sequel to Secret of Mana]
Soul Blazer*- 443 [arguably affiliated with Illusion of Gaia/Terranigma/Granstream Saga]
The 7th Saga*- 310 [Mystic Ark is a quasi-sequel to this game]
Uniracers- 214
Stunt Race FX- 202
Robotrek- 180
Brain Lord- 160
Arcana- 134
Super Scope 6- 134
Skyblazer- 107
Metal Warriors*- 99 [Marketed as a sort-of follow-up to Cybernator]
Plok- 98
Tecmo Secret of the Stars- 96
Hagane- 82
Claymates*- 79 [Clayfighter was a sort-of follow-up to this game]
Lester the Unlikely- 71
Young Merlin- 59
King Arthur’s World- 54
Hyperzone- 52
Run Saber- 50
X-Kaliber 2097- 48
Ardy Lightfoot- 47
Xardion- 45
Nosferatu- 43
Tin Star- 39
Smart Ball- 36
Tuff E Nuff- 35
Vortex- 33
D-Force- 32
Big Sky Trooper- 30
Dirt Trax FX- 29
ASP: Air Strike Patrol- 28
Battle Cars- 28
Captain Novolin*- 27 [arguably affiliated with Rex Ronan/Bronky/Packy & Marlon]
Rocky Rodent- 26
Super Pinball: Behind the Mask*- 26
Extra Innings- 25
Firestriker- 25
HAL’s Hole in One Golf*- 25 [JP version features Jumbo Ozaki]
Musya- 25
Cacoma Knight in Bizyland- 24
Harley’s Humongous Adventure- 24
Time Slip- 19
Imperium- 18
Bazooka Blitzkrieg- 17
Cyber Spin*- 16 [JP version is based on Future GPX Cyber Formula]
Power Piggs of the Dark Age- 16
Dig & Spike Volleyball- 15
Pieces- 15
World Soccer ’94: Road to Glory- 15
Carrier Aces- 14
Doomsday Warrior- 14
Frantic Flea- 14
Hammerlock Wrestling*- 14 [JP version features Genichiro Tenryu]
Incantation- 14
Skuljagger: Revolt of the Westicans- 13
RPM Racing*- 12
Shien’s Revenge- 12
X-Zone- 12
Battle Grand Prix- 11
Realm- 11
Air Cavalry- 10
Metal Morph- 10
Mohawk and Headphone Jack- 10
Bronkie the Bronichiasaurus- 9 [arguably affiliated with Packy & Marlon/Rex Ronan/Captain Novolin]
Full Throttle All-America Racing- 9
Rex Ronan: Experimental Surgeon*- 9 [arguably affiliated with Packy & Marlon/Bronky/Captain Novolin]
Super Slap Shot*- 9 [apparently endorsed by Gordie Howe, not clear if it actually features him though]
International Tennis Tour- 8
Dream TV- 7
Space Football- 6
Mecarobot Golf*- 5 [JP version features Nobuo Serizawa
Street Hockey ’95- 5
Packy & Marlon*- 4 [arguably affiliated with Rex Ronan/Bronky/Captain Novolin]
Football Fury- 3
TKO Super Championship Boxing*- 5 [JP version features Jiro Matsushima on the cover]
PS1: 102 games out of 1243
Thousand Arms- 228
Beyond the Beyond- 204
Evil Zone- 128
The Granstream Saga- 128 [sort-of-related to Soul Blazer/Illusion of Gaia/Terranigma]
Omega Boost- 117
Wild 9- 107
Shadow Madness- 106
Apocalypse- 103 [uses Bruce Willis's voice and likeness and so might be considered a licensed game]
Eternal Eyes- 91
Akuji the Heartless- 65
Incredible Crisis- 65 [may have been released twice in Europe; info is unclear]
Tail Concerto- 63 [Solatorobo on the DS is a sort-of-sequel to this game]
Blasto- 59
Ninja: Shadow of Darkness- 55
Soul of the Samurai- 54
Rogue Trip: Vacation 2012- 52 [unofficial sequel to Twisted Metal 1/2]
The Unholy War- 51
Project Overkill- 49
Team Buddies- 47
Cardinal Syn- 46
Speed Punks- 45
Monsterseed- 43
Covert Ops: Nuclear Dawn- 42
Disruptor- 42
T'ai Fu: Wrath of the Tiger- 42
Treasures of the Deep- 41
Tiny Tank- 39
Countdown Vampires- 38
Elemental Gearbolt- 38
Rascal- 33
Grind Session- 32 [some skaters are licensed]
No One Can Stop Mr. Domino- 32
Monkey Hero- 30
Spider: The Video Game- 30
Kensei: Sacred Fist- 28
Project Horned Owl- 28
Trap Gunner- 28
Kingsley's Adventure- 27
Mort the Chicken- 23
Assault: Retribution- 21
One Piece Mansion- 20
Auto Destruct- 19
Power Moves Pro Wrestling- 19 [sort-of spinoff of Toukon Retsuden]
Broken Helix- 16
Boombots- 15
Circuit Breakers- 15
Eagle One: Harrier Attack- 15
Space Griffon VF-9- 15
NGEN Racing- 14
Running Wild- 14
Cyberspeed- 13
Juggernaut- 13
No Fear Downhill Mountain Biking- 13
Steel Reign- 13
Dead Ball Zone- 12
Grudge Warriors- 12
Killing Zone- 12
Invasion from Beyond- 11
Nanotek Warrior- 11
RC Revenge- 11 [sort-of-spinoff of Re-Volt]
R/C Stunt Copter- 11
Steel Harbinger- 11
Bogey Dead 6- 10
Punky Skunk- 10
Tennis- 10
All Star Racing- 9
Psybadek- 9
RC de Go!- 9 [sort-of related to RC Revenge/Re-Volt]
Big Air- 8 [contains licensed snowboarding gear]
Big Strike Bowling- 8
Burning Road- 8
Floating Runner- 8
Pitball- 8
Rush Hour- 8
Saltwater Sportfishing- 8
Family Game Pack- 7
Professional Underground League of Pain- 7
American Pool- 6
Blast Radius- 6
Bug Riders- 6
Dare Devil Derby 3D- 6
Starwinder- 6
Surf Riders- 6
Vanark- 6
Patriotic Pinball- 5
Phix: The Adventure- 5
VMX Racing- 5
The Bombing Islands- 4 [almost the same game as Charlie Blast's Territory on N64]
Super Shot Soccer- 4
Eggs of Steel- 3
Freestyle Boardin' '99- 3
Rushdown- 3
Trick'N Snowboarder- 3 [arcade predecessor?]
ATV Mania- 2
The Final Round- 2
Power Serve 3D Tennis- 2
Burstrick: Wakeboarding- 1
Easter Bunny's Big Day- 1
Family Card Game Fun Pack- 1
Slots- 0
Tecmo World Golf- 0
World Cup Golf- 0 [licensed game?]
N64: 23 games out of 296
Jet Force Gemini- 691
Blast Corps- 425
Mischief Makers- 394
Body Harvest- 190
Hybrid Heaven- 146
Buck Bumble- 101
Rocket: Robot on Wheels- 97
Iggy's Reckin' Balls- 90
Aerogauge- 54
MRC: Multi-Racing Championship- 44
Deadly Arts- 42
Chopper Attack- 35
World Driver Championship- 33
Knife Edge: Nose Gunner- 31
Dual Heroes- 30
Virtual Chess 64- 30
GT 64: Championship Edition- 27 [may be a licensed game]
Charlie Blast's Territory- 20 [re-skinned version of The Bombing Islands on PS1]
Milo's Astro Lanes- 19
Twisted Edge Extreme Snowboarding- 19
Bassmasters 2000- 15
Stunt Racer 64- 14
Big Mountain 2000- 10
PS2: 90 games out of 1831
Radiata Stories- 906
The Bouncer- 472
Okage: Shadow King- 253
Shadow of Rome- 218
Rule of Rose- 209
Eternal Poison- 184
Ephemeral Fantasia- 169
Extermination- 142
Urban Reign- 124
Eternal Ring- 114
Bujingai: The Forsaken City- 113
Dog's Life- 102
Rise to Honor- 101 [features voice and likeness of Jet Li]
Ghosthunter- 97
Tourist Trophy- 94 [licensed vehicles]
Crimson Tears- 88
Kuon- 79
Cold Winter- 78
Downhill Domination- 75
Kya: Dark Lineage- 75
Samurai Western- 72
EOE: Eve of Extinction- 70
RAD: Robot Alchemic Drive- 69
Nanobreaker- 64
Skygunner- 64 [sequel on PC?]
Kinetica- 57
Haven: Call of the King- 54
Tsugunai: Atonement- 54
S.L.A.I.: Steel Lancer Arena International- 51 [sequel to Phantom Crash?]
Enthusia Professional Racing- 50
Airblade- 48
Stretch Panic- 48 [released by two different publishers in Europe]
Rumble Racing- 46 [unofficial sequel to NASCAR Rumble]
Sky Odyssey- 44
Spy Fiction- 41
The Legend of Alon D'ar- 39
Lifeline- 39 [two SKUs released in Japan]
Legion: The Legend of Excalibur- 33
Under the Skin- 31
DT Racer- 30
Dark Angel: Vampire Apocalypse- 29
X-Squad- 29
Dragon Rage- 28
Herdy Gerdy- 28
The Adventures of Darwin- 26 [part of the "Simple 2000" label in Japan]
HSX Hypersonic Xtreme- 25
Dance Factory- 24 [licensed music]
Driving Emotion Type-S- 24 [contains licensed cars]
Brave: The Search for Spirit Dancer- 21
Endgame- 21 [released twice in Europe]
Godai Elemental Force- 21
Summer Heat Beach Volleyball- 21
Super Trucks Racing- 21 [contains licensed trucks]
Firefighter F.D. 18- 20
Fugitive Hunter: War on Terror- 16
Yanya Caballista: City Skater- 16
Dropship: United Peace Force- 15
Music Maker- 15
Shox- 15 [contains licensed cars]
Flipnic: Ultimate Pinball- 14
Motor Mayhem- 14
Sub Rebellion- 13
Swing Away Golf- 13 [Disney Golf is sort-of a sequel to this game]
eJay Clubworld- 12 [contains licensed clubs]
Pryzm Chapter One: The Dark Unicorn- 12
Surfing H3O- 12
Wild Wild Racing- 12
City Crisis- 11
My Street- 11
RTX Red Rock- 10
Fisherman's Bass Club- 9 [sort-of sequel to Bass Hunt]
Hidden Invasion- 9
Jet X2O- 9
Wave Rally- 8
Real Pool- 7
Eagle Eye Golf- 6
Iridium Runners- 6
MX Rider- 6 [contains licensed tracks]
Bass Strike- 5
Flow: Urban Dance Uprising- 5
Get On Da Mic- 5 [licensed soundtrack]
Unison: Rebels of Rhythm & Dance- 5 [contains licensed music]
Global Touring Challenge: Africa- 4 [contains licensed cars]
Riding Spirits- 4 [contains licensed motorcycles]
Women's Volleyball Championship- 4 [Japanese version carries FIVP license]
World Championship Paintball- 4
Short Track Racing: Trading Paint- 3
Fisherman's Challenge- 2
Lowrider- 2
Karaoke Party- 0
Xbox: 38 games out of 891
Brute Force- 135
Breakdown- 131
Phantom Dust- 127
Gunvalkyrie- 115
Phantom Crash- 62 [SLAI for PS2 is sort-of a sequel to this game]
Voodoo Vince- 60
Kung Fu Chaos -59
Azurik- 48
Tao Feng: Fist of the Lotus- 46 [pretty much an unofficial Mortal Kombat game]
Quantum Redshift- 41
Whacked- 29
Deathrow- 25
Metal Dungeon- 21
Apex- 20
Mad Dash Racing- 20
Kakuto Chojin- 19
Black Stone: Magic & Steel- 18
Galleon- 17
New Legends- 17
Stake: Fortune Fighters- 16
Murakumo: Renegade Mech Pursuit- 15
Pulse Racer- 12
Chase: Hollywood Stunt Driver- 10
Kabuki Warriors- 10
Classified: The Sentinel Crisis- 9
Maximum Chase- 9
Sneakers- 8
Tork: Prehistoric Punk- 8
Carve- 7
Championship Bowling- 6
Iron Phoenix- 6
Pro Fishing Challenge- 6
Pro Cast Sports Fishing- 5 [part of the Lake Masters series?]
Knight's Apprentice: Memorick's Adventures- 4
Group S Challenge- 3 [features licensed cars]
Seablade- 3 [released as bundle with Outlaw Golf]
Toxic Grind- 2
Furious Karting- 1
Gamecube: 11 games out of 566
Eternal Darkness- 938
Geist- 233
PN 03- 212
Gotcha Force- 182
Cubivore- 111
Amazing Island- 110
Odama- 90
Go! Go! Hypergrind- 16
Tube Slider- 13
Swingerz Golf- 8
MC Groovz Dance Craze- 7 [contains licensed music]
Suggested games from other platforms (up to the end of page 11):
3D Dot Game Heroes (PS3)
Afrika (PS3)
Albion (DOS)
Arc Rise Fantasia (Wii)
Art Style: Pictobits (DS)
ASH: Archaic Sealed Heat (DS)
Astal (Saturn)
Battle Circuit (arcade)
Blade Force (3DO)
Bounty Hounds (PSP)
Bulk Slash (Saturn)
Buriki One (arcade)
Burning Rangers (Saturn)
Chromehounds (Xbox 360)
Code of Princess (3DS)
Contact (DS)
Cosmic Carnage (32X)
Crashday (Windows)
Dark Savior (Saturn) [borderline, arguable sequel to Landstalker]
The Dark Spire (DS)
Dark Wizard (Sega CD)
Dead Head Fred (PSP)
Deadly Creatures (Wii)
Deep Fear (Saturn)
Demon Front (arcade)
Demon's Souls (PS3) [borderline, Dark Souls is the sequel in all but name]
Disaster: Day of Crisis (Wii)
Dolphin Blue (arcade)
Drill Dozer (GBA)
Elemental Gimmick Gear (Dreamcast)
Elite Beat Agents (DS) [borderline, arguable spinoff of Ouendan]
Enemy Zero (Saturn) [borderline; features digital actress Laura, who previously starred in D]
Eschatos (Xbox 360)
Farjius no Jakoutei: Neo Metal Fantasy (PCE)
Fighting Layer (arcade)
Folklore (PS3)
Fragile Dreams (Wii)
Freedom Wars (Vita)
Gravity Rush (Vita)
Heavenly Sword (PS3)
Henry Hatsworth in the Puzzling Adventure (DS)
Hexyz Force (PSP)
Illbleed (Dreamcast)
Impossible Creatures (Windows) [had a few expansions, though]
Infinite Space (DS)
Jeanne d'Arc (PSP)
Kameo: Elements of Power (Xbox 360)
Kolibri (32X)
The Last Story (Wii)
LOL: Lack of Love (Dreamcast)
Lost Odyssey (Xbox 360)
Lunacy (Saturn)
Maboshi's Arcade (Wii)
Martial Masters (arcade)
Metal Fatigue (Windows)
Metal Head (32X)
Metropolis Street Racer (Dreamcast) [borderline, PGR was arguably a sequel]
Natatsu Kaze no Shima Monogatari (Saturn)
Night Slashers (arcade)
Nightmare in the Dark (arcade)
Ninja Baseball Bat Man (arcade)
Ninja Five-O (GBA)
Omega Five (Xbox 360)
One Way Heroics (Windows)
Opoona (Wii)
Osman (arcade) [borderline, unofficial sequel to Strider]
The Outfoxies (arcade)
Outlaws (Windows)
Penguin Land (SMS)
Prop Cycle (arcade)
Puppeteer (PS3)
Radiant Historia (DS)
Rain (PS3)
Red Dog: Superior Firepower (Dreamcast)
Rocket Jockey (Windows)
Shadow Complex (Xbox 360)
Soul Bubbles (DS)
Super Magnetic Neo (Dreamcast)
Teleroboxer (Virtual Boy)
Terra Phantastica (Saturn)
Too Human (Xbox 360)
Trinity (Z-Machine) [borderline, released on Z-Machine]
Wachenroder (Saturn)
Wake-up Club (Vita)
The Wonderful 101 (Wii U)
Yume Nikki (Windows)
Zack & Wiki (Wii)
ZHP: Unlosing Ranger vs. Darkdeath Evilman (PSP)
ZombiU (Wii U) [Note: some sources say it's a sequel to Zombi, but the devs said it's not]