Senators are expected to vote Tuesday on the nomination of Betsy DeVos for education secretary. She is expected to be confirmed, with Vice President Mike Pence casting the tie-breaking vote. All 48 members of the Democratic caucus and two Republicans -- Sens. Lisa Murkowski and Susan Collins -- oppose DeVos, but Pence would give Republicans the one extra vote they need.
http://www.cnn.com/2017/02/06/politics/devos-session-senate-vote-tuesday/
So for those catching up DeVos' appointment has basically been under siege from virtually every side for a while now. Two Republican senators have folded, but we need 3 to block since Pence can just break what will be the 50/50 split in favor of Devos. As it stands she's going to slide in, Sessions is assumed to enter no problem as well. Remember all you need is a simple majority so without bipartisan support in rejecting a nomination, Dems have no clout.