IMHO, Venture Brothers is the best original Adult Swim series. I like Sealab and ATHF as much as the next person, but Venture is, well, to me more sophisticated in its humor. (Except when it's trying to be crass.) It credits the viewer with thinking a little more, and is less LOLOLOLOL every 5 seconds because it's intentionally more subdued and takes longer to set up punchlines. Seriously, at times I've started giggling an hour after the show as something fully sank in. I consider that to be a good thing - it makes me want to watch it again right away.
Doc Venture being more sardonic than delivery man for funny lines fits perfectly, in my view. He's the wet blanket and foil essentially, as well as being the straight man at times. He's not laugh out loud funny, but is enoyable to watch in action.
Unfortunately, Venture may end up not making it because it's not stereotypically Adult Swim enough for Adult Swim. Bleh. But it's not like this is a new phenomenon.