I'm a bit late to the party, but here are my predictions sorted into two categories:
Likely:
-A focus on Amiibos and their compatibility with various games. I think this will be the main focus of the direct.
-Talk about the New 3DS release in the West. Maybe a specific release date, most likely a release window.
-Games: Yoshi's Wooly World, Kirby Rainbow Curse, Splatoon, Smash Bros U (reveal trailer for
), S.T.E.A.M, Mario Maker, Xenoblade Remake
-Bundles
Unlikely:
-Zelda U, Majora's Mask remake (I don't think it even exists), Xenoblade X, FE x SMT, Star Fox U
-Discussion about QoL
-System updates for either console