I'm actually surprised to hear that people didn't pick up on Comstock being the fully realized anti-christ if they figured out that Booker was also the anti-christ. I mean, the whole scene where Booker tries to find comstock as a baby and kill him, and the fact that elizabeth drowns Comstock/Booker simultaneously in the first instance of the Comstock timeline should really make that clear.
On the subject of the thread again, I'm not sure I fully agree with your interpretation of plasmids. I agree that they're similiar to heroine, in that it's highly addictive. However, I don't believe that everyone would start using heroine if it were made legal like in Bioshock, and I think Bioshock itself provides that explanation. It's the ultility of plamids that sets them apart. It's the ultility that gets Jack to jam that first needle, after which he becomes a destructive splicer. I'd think a better paralell might be if heroine were injected into McDonald's hamburgers. People would come to eat the burger, but end up getting hooked and high from the heroine. Still, the message is essentially the same about regulation.
I'd actually be curious to see what you'd think of Catherine. I think you'd have a field-day with it. I mean I've seen a well-detailed several page write-up about its
start screen alone.