The story arcs from BBT where the characters have to deal with growing out of a self-perpetuated man child stage are the most poignant, possibly because they hit pretty close to home.
For instance, in one of the earlier seasons, there's a female physician Howard meets at a club while trolling for booty. He takes her to work on the promise that she will get to drive a Mars rover by remote. Of course, it all goes horribly wrong and he ends up screwing up a multi billion dollar mission because of it. Who amongst us hasn't tried their darnedest to impress a girl only to have it all go wrong?
Later in that same season, the same girl starts dating Leonard and practically moves in with him, spending so much time at his place that Sheldon starts demanding she pay rent. When she suggests that she and Leonard just stop pretending and move in together for real, it exposes a bunch of commitment issues Leonard has, he being content for the half-arsed status quo to continue. I watched that episode with my then girlfriend (now wife) while we were having the exact same conflict and it gave me all sorts of uncomfortable feels.
Not to mention Howard's arrested development and codependent relationships (his mum, Raj), Raj's crippling social anxiety and dealing with being a brown boy in a dating market where whiteness is the default and Sheldon's grappling with the mundane interactions we all take for granted. Add Penny's nonexiststent acting career, Amy's endearing attempts to make up for a lonely friendless childhood in adulthood (and homoerotic admiration for Penny) as well as Bernadette's obliviousness to so many of Howard's flaws and you get a great show.
That's what the show is about, not some throwaway geek references here and there. If Leonard and Sheldon had a poster of a hot rod up beside their door instead of a replica of the Valyrian steel greatsword Ice, the jokes would work exactly the same way.
But sure, trot out the Bazinga hate if that's your thing.