Yes
It depends on your car, the station and your state regulations.
Your Car: Sometimes your car requires a higher octane. if it says use regular, then there's no harm in using regular, but...
Station: If it's a cheap gas station, not just a cheap brand, you might want to be careful. A lot of these places can charge less because they have cheap fuel or they charge less simply because of faults. Some stations are old/crappy and have water in their tanks. That's why you should never fill up when you see a gas truck leaving a station. When he puts all that gasoline in there it stirs up the water and you have a higher chance of getting water in your system. And if you see a gas truck that hasn't put it in, same deal for the same reason. But sometimes, gas stations will just get good deals on a shipment of gas etc. So look for these patterns in stations in your neighborhood and such.
State Regulations: State regulations vary. Like when I lived in NM, getting regular for my car was not an option because the state had no regulations on cleansers and such in the gas and if a company didn't opt for that on their own, you could get some really nasty gas. so i always got the mid ranger gas just to be sure. But it varies so check out your state. mostly ones with exhaust regulations will have better gasoline regulations.