Im currently running Windows 8 Pro at home, and have been for several weeks now. Its my main OS and runs everything flawlessly. Big upgrade from Windows 7 and I won't be going back. I've also upgraded my work laptop from Windows 7 Enterprise to Windows 8 Enterprise and have no compatibility issues thus far with any work applications. Also running Lync 2013, Office 2013 and a few other new suites of MS applications as well.
I've been running variants of Windows 8 and 2013 suite applications for awhile as one of 6 companies world wide participating in the Super TAP program. Everything has come such a long long way in the past 18 months, and these final builds are ready to go. It will be interesting to see how things go from here, SDKs out there and all and developers starting to release WinRT applications etc..
I would have told you 1 month ago that Windows 8 would seem like the slowest adopted Windows OS yet, based on some of the feedback I read online. But, to the contrary most family and friends around me are interested in upgrading the OS or buying a Surface very soon. Shocking to have even my parents excited about the changes and new OS.. technology really has become a mainstream consumer electronic. People want the 'new' thing so I think Windows 8 will do just well.
That won't stop a few bitter PC enthusiasts upset with change, from making as much noise as they can online. MS will do just fine.