Left my girlfriend, job and friends to move to another country to pursue my dream of studying for and working in the games industry. I've done this twice, in 2 different countries, with 2 different girls and jobs.
The third time, just when I had finally landed my perfect dream job in Japan, a girl comes along and suggests I drop everything to move with her to Europe. I shrugged, said "why not?" and just left everything and moved away with her. Liberating. The cliche that goes "luck favors the brave" has been especially true in my case, as every time I've left something seemingly big and important behind, I've always found something much, much greater waiting for me over the horizon.
Currently, I have a much better "dream job" here than I ever hoped, with a salary much higher than I need, and I still wake up blissfully happy next to the same girl after over 4 years of being happily together.