I imagine this will cover pretty much everything left in the Nintendo development tank for the WiiU and 3DS. So expect updates on Xenoblade X, M. Tennis, Amiibo Festival, Devil's Third, Star Fox Zero, FE#, Federation Force, FE Fates, Hyrule Warriors Legends, Badge Arcade, and Paper Jam. If TP HD actually exists, it will be announced here, along with a reconfirmation that open-world Zelda will still release on WiiU (most likely Q4 2016). Zelda's 30th anniversary will be celebrated in many more ways as well. Miitomo and the new MyNintendo account system will be covered, along with a reconfirmation that Nintendo is working on NX for dedicated gamers and will share more information "early" next year.
Don't expect any NX details past that. This direct is solely to tie up any loose ends left from the WiiU and 3DS before moving froward.