Mask Efficacy |OT| Wuhan!! Got You All In Check

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One study has show chloroquine causes heart problems in patients.

Another showed smokers are less prone to severe COVID symptoms than non smokers.
Drug has been in use for 60 years. It's safe. Like with ALL medication there are potential for side effects. Heart Arrhythmia is a rare side effect of using the medication. Not everyone that uses the medication is going to develop heart issues.
 
there's conflicting info re: (cursory) triage data v. established literature

further reading -->


 
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I think the Doctors didn't prescribe it properly, the amount they gave looks higher than what I have seen suggested.

The Brazilian study included 81 hospitalized patients, with about half being given a dose of 50 milligrams of chloroquine twice daily for five days. The other participants were prescribed a dose of 600 milligrams for 10 days.

Patients taking higher doses experienced heart arrhythmias, or improper beating of the heart, within three days, according to the study. Eleven patients died by the sixth day of treatment and caused the research on high-dosages to end.

"Preliminary findings suggest that the higher CQ dosage (10-day regimen) should not be recommended for COVID-19 treatment because of its potential safety hazards," the study's abstract said. "Such results forced us to prematurely halt patient recruitment to this arm."

The lower-dosage portion of the study did not include enough patients to gauge whether it is effective in treating severely ill patients, the Times noted. The researchers said that more studies assessing the efficacy of chloroquine are "urgently needed."


They gave 6 times the amount to people with severe COVID. And it doesn't tell us their comorbities. Its possible they may of had heart conditions as an underlying condition. And the researchers themselves call for more studies into the drug at lower dosages.

Millions of people take this stuff for decades who have RA or lupus. I am not saying it will work against COVID, but if you are using it make sure a phsyician is giving it to you and monitoring the progress.
 
cofactor elements here, smoking might be a gateway to infection but stave deeper air sac damage

heart and testicle damage is worrying, either way the disease is a man killer in the fullest sense
 
On a lighter note, I found myself watching Jimmy Kimmel and it was somehow even worse than the usual late night "funny" man quality. He seems to be purposefully doing the show in awful locations for audio and keeps pausing for laughter at his awful jokes. The whole thing feels so patronizing.
 
The heart problem thing has been known about it. CCPNN is amplifying that for a reason that isn't hard to figure out.

Swedish hospitals also stopped giving the drug for that reason. Early results from French studies also identified 54 suspicious cases (including 7 deaths) of severe complications due to the drug. But let's make it all about China.

I think the Doctors didn't prescribe it properly, the amount they gave looks higher than what I have seen suggested.

The Brazilian study included 81 hospitalized patients, with about half being given a dose of 50 milligrams of chloroquine twice daily for five days. The other participants were prescribed a dose of 600 milligrams for 10 days.

600 mg is the amount recommended by Didier Raoult, the French doctor who's been pushing it and is often said to be the person with the most knowledge of that drug worldwide (being an expert on tropical diseases). Which is why people are cautious with that whole hidroxychloroquine stuff : the way it's used to fight covid-19 isn't the standard posology, nor are patients standard patients.
 
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Sweden hospitals also stopped giving the drug for that reason. Early results from French studies also identified 54 suspicious cases (including 7 deaths) of sever complications due to the drug. But let's make it all about China.



600 mg is the amount recommended by Didier Raoult, the French doctor who's been pushing it and is often said to be the person with the most knowledge of that drug worldwide (being an expert on tropical diseases). Which is why people are cautious with that whole hidroxychloroquine stuff : the way it's used to fight covid-19 isn't the standard posology, nor are patients standard patients.

Yeah. People keep putting out that that CQ and HCQ are "safe" because they've been around for ages, but the COVID19 doses are higher than standard prescribed doses and even those have known toxicities that need to be monitored. We're assuming that they'll be safe because we're using them for short periods, but there is no guarantee of that.
 
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Yeah. People keep putting out that that CQ and HCQ are "safe" because they've been around for ages, but the COVID19 doses are higher than standard prescribed doses and even those have known toxicities that need to be monitored. We're assuming that they'll be safe because we're using them for short periods, but there is no guarantee of that.

Virtually all drugs have side effects, some more severe than others - there is no guarantee of safety for any drug, just a manageable risk. That said, high doses are at least tolerable for at least 4-5 days. While interim, this has been demonstrated via University of Minnesota's clinical trial.

Dosing regime here: https://clinicaltrials.gov/ct2/show/NCT04308668 (800mg + 600mg! day 1, then 600mg/day thereafter)
Most recent update here: https://covidpep.umn.edu/updates

There have also been studies (albeit small cohort, <100 I think) of patients receiving 600mg/day for either 30 or 60 days with no serious adverse events and only non-serious adverse events (ie. upset stomach/diarrhea, headache) etc.
 
On a lighter note, I found myself watching Jimmy Kimmel and it was somehow even worse than the usual late night "funny" man quality. He seems to be purposefully doing the show in awful locations for audio and keeps pausing for laughter at his awful jokes. The whole thing feels so patronizing.
Looking at Kimmel's recent stuff, I'm happy to see that at least he's classing it up by using a good video camera and mic, instead of doing what everyone else is doing, which is shooting on a phone camera or shitty laptop camera. For chrissakes, all these people work in showbiz and have access to tons of expensive equipment, and yet everyone's shooting everything on a 720p webcam at 10 fps. Props to Kimmel.
 


Straight up thought Norway had pulled the greatest reform of a convict in the history of mankind:

le-tueur-norvegien-d-extreme-droite-anders-behring-breivik-au-tribunal-d-oslo-le-24-aout-2012_4754203.jpg
 
Very few countries, including ones with questionable reporting (especially Asian countries like Japan which had ◯‍◯‍◯‍◯‍◯ reasons to lie).

Germany is really the only country that seemed to respond very well.

The US has performed better than most European countries, as evidenced by our per capita stats. I'm not sure what else the US really could have done - unlike Germany, we have a very decentralized government, but even then we have done well.



Where?

This is false, Portugal has reacted incredibly well, Hungary has also reacted incredibly well and other small countries have as well, even better than germany. Although germany has made very good work, their numbers are low because of their financial resources, not necessarily their plan of action, they have been praising a few other countries on this that have acted extremely well with little resources.
 
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Germany is really the only country that seemed to respond very well.



PS
Germany f*cked up royally not banning mass gatherings at "Carnival" (end of Feb).
Not as bad as feminist March of 8th of March in Spain, but still, significant.

Other than that, Germany is a federation, with each state having own government.
And each state had independent lockdown timeline, Bayern, for instance, was among the first (and the harshest). They also happen to be rather close to Italy.

As far as healthcare goes, clinics within a city, is that city's problem.
 
I think the Doctors didn't prescribe it properly, the amount they gave looks higher than what I have seen suggested.

The Brazilian study included 81 hospitalized patients, with about half being given a dose of 50 milligrams of chloroquine twice daily for five days. The other participants were prescribed a dose of 600 milligrams for 10 days.

Patients taking higher doses experienced heart arrhythmias, or improper beating of the heart, within three days, according to the study. Eleven patients died by the sixth day of treatment and caused the research on high-dosages to end.

"Preliminary findings suggest that the higher CQ dosage (10-day regimen) should not be recommended for COVID-19 treatment because of its potential safety hazards," the study's abstract said. "Such results forced us to prematurely halt patient recruitment to this arm."

The lower-dosage portion of the study did not include enough patients to gauge whether it is effective in treating severely ill patients, the Times noted. The researchers said that more studies assessing the efficacy of chloroquine are "urgently needed."


They gave 6 times the amount to people with severe COVID. And it doesn't tell us their comorbities. Its possible they may of had heart conditions as an underlying condition. And the researchers themselves call for more studies into the drug at lower dosages.

Millions of people take this stuff for decades who have RA or lupus. I am not saying it will work against COVID, but if you are using it make sure a phsyician is giving it to you and monitoring the progress.


There are literally a lot of people in Brazil rooting against chloroquine just because they hate the president and he's been talking this medicine for a long time now. It's totally clown world. Most part of the mainstream media goes along with this bullshit.
 

"If a Californian is able to go to Costco or the local marijuana shop or liquor store and buy goods in a responsible, socially distanced manner, then he or she must be allowed to practice their faith using the same precautions," she said in a statement.
 
Germany is really the only country that seemed to respond very well. The US has performed better than most European countries, as evidenced by our per capita stats. I'm not sure what else the US really could have done - unlike Germany, we have a very decentralized government, but even then we have done well.

The US had a very good starting point but one of the worst responses.
I think the ICUs are at around 26 per 100.000 citizens, which is way higher than the 7-9 per 100.000 you'll find in many southern European countries.

So capacity is high and the way states work together during crisis should have allowed the US to avoid going over capacity.
But the US fucked up testing as well as the proper crisis communication.

In January or early February three things should have been done and communicated:
1. Testing infrastructure needs to be ramped up all across the country
2. Contact trace, as long as that is possible. That means you trace infection chains and only quarantine select few people.
3. Once contact tracing fails(likely scenario) a shutdown has to be implemented nationwide until infections are so low that contact tracing works again.

The US lost at least 2 months on testing, which made contact tracing impossible.
No clear messaging on the shutdown, which resulted in many states shutting down way too late, so the flattening the curve attempt also came several weeks too late.

Now the next step is going back to contact tracing, which requires the curve to flatten to the point that testing and tracing capacities are able to trace all infection chains. Once that works you can think about slowly reopening the economy again.
But that is not communicated clearly.

So when it comes to ICUs, the US was in a good position.
But everything else was a complete disaster.
Considering that the US was hit later than Europe and considering the per capita ICUs, I'd say that with a proper response by the US government the death toll could have been kept below 10.000 in total.


Here is a top 40 of the safest countries during this crisis, unsurprisingly the US didn't make the list.

EViaKrQWAAIuAEP
 
The new coronavirus can survive long exposure to high temperatures, according to an experiment by a team of French scientists.

Professor Remi Charrel and colleagues at the Aix-Marseille University in southern France heated the virus that causes Covid-19 to 60 degrees Celsius (140 Fahrenheit) for an hour and found that some strains were still able to replicate.

The scientists had to bring the temperature to almost boiling point to kill the virus completely, according to their non-peer-reviewed paper released on bioRxiv.org on Saturday. The results have implications for the safety of lab technicians working with the virus.


The team in France infected African green monkey kidney cells, a standard host material for viral activity tests, with a strain isolated from a patient in Berlin, Germany. The cells were loaded into tubes representing two different types of environments, one "clean" and the other "dirty" with animal proteins to simulate biological contamination in real-life samples, such as an oral swab.

After the heating, the viral strains in the clean environment were thoroughly deactivated. Some strains in the dirty samples, however, survived.

The heating process resulted in a clear drop in infectivity but enough living strains remained to be able to start another round of infection, said the paper.

There has been rapidly increasing demand around the world to perform tests on the new coronavirus. But some of the work has had to be performed in less protected laboratories. Technicians in these labs were directly exposed to the samples, requiring that they be "deactivated" before further processing.

The 60-degrees Celsius, hour-long protocol has been adapted in many testing labs to suppress a wide range of deadly viruses, including Ebola.

For the new coronavirus, this temperature may be enough for samples with low viral loads because it could kill a large proportion of the strains. But it may be dangerous for samples with extremely high amounts of the virus, according to the researchers.

The French team found a higher temperature could help solve the problem. For instance, heating the samples to 92 degrees Celsius for 15 minutes could render the virus completely inactive.

However, such high temperatures could also severely fragment the virus' RNA and reduce the sensitivity of the test. The researchers therefore suggested using chemicals instead of heat to kill the virus and strike a balance between the safety of lab workers and detection efficiency.

"The results presented in this study should help to choose the best suited protocol for inactivation in order to prevent exposure of laboratory personnel in charge of direct and indirect detection of Sars-CoV-2 for diagnostic purpose," wrote the authors.

A microbiologist studying the coronavirus at the Chinese Academy of Sciences in Beijing said Chinese test facilities were aware of the risk to lab workers and took extra precautions.

All staff must dress in a full hazmat suit when handling the virus samples, even after deactivation, among other measures.
 
The US had a very good starting point but one of the worst responses.
I think the ICUs are at around 26 per 100.000 citizens, which is way higher than the 7-9 per 100.000 you'll find in many southern European countries.

So capacity is high and the way states work together during crisis should have allowed the US to avoid going over capacity.
But the US fucked up testing as well as the proper crisis communication.

In January or early February three things should have been done and communicated:
1. Testing infrastructure needs to be ramped up all across the country
2. Contact trace, as long as that is possible. That means you trace infection chains and only quarantine select few people.
3. Once contact tracing fails(likely scenario) a shutdown has to be implemented nationwide until infections are so low that contact tracing works again.

The US lost at least 2 months on testing, which made contact tracing impossible.
No clear messaging on the shutdown, which resulted in many states shutting down way too late, so the flattening the curve attempt also came several weeks too late.

Now the next step is going back to contact tracing, which requires the curve to flatten to the point that testing and tracing capacities are able to trace all infection chains. Once that works you can think about slowly reopening the economy again.
But that is not communicated clearly.

So when it comes to ICUs, the US was in a good position.
But everything else was a complete disaster.
Considering that the US was hit later than Europe and considering the per capita ICUs, I'd say that with a proper response by the US government the death toll could have been kept below 10.000 in total.


Here is a top 40 of the safest countries during this crisis, unsurprisingly the US didn't make the list.

EViaKrQWAAIuAEP

Another example of the bullshit that is flying around proclaiming to be truth.

Anyway, it can't be truth because another apparent reliable source, bnonews.com, places Germany 5th on the danger list with a 2.46% death rate, so how the fuck they're number 2 on the safe list is beyond fearmongering crap.

Israel have a 1% death rate, and they are number one safe country in the world, closer.

But I live in Slovakia and we have a 0.27% kill rate. 2 people died out of 5.5 million population. I see it's number 38 on that list. Proves every model is just lies and falsehoods. Something fishy is going on over here, the country is never first for anything but during this crisis we've been one of the European counties to initiate shutdowns and draconian measures first. Easter had the army enforcing absolute no travel law. I'm betting now that we'll be one of the first countries to get Bill Gate's Glorious Elixir. Hope I'm wrong for my children's sake. Didn't the dodgy bastard go on TV at the weekend and say millions will die from side-effects?

But I guess the definition of safety in the above chart is different to my definition of safety here. Models won't save us though, everyday is a new model, it's pure shite.
 
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Another example of the bullshit that is flying around proclaiming to be truth.

Anyway, it can't be truth because another apparent reliable source, bnonews.com, places Germany 5th on the danger list with a 2.46% death rate, so how the fuck they're number 2 on the safe list is beyond fearmongering crap.

Israel have a 1% death rate, and they are number one safe country in the world, closer.

But I live in Slovakia and we have a 0.27% kill rate. 2 people died out of 5.5 million population. I see it's number 38 on that list. Proves every model is just lies and falsehoods. Something fishy is going on over here, the country is never first for anything but during this crisis we've been one of the European counties to initiate shutdowns and draconian measures first. Easter had the army enforcing absolute no travel law. I'm betting now that we'll be one of the first countries to get Bill Gate's Glorious Elixir. Hope I'm wrong for my children's sake. Didn't the dodgy bastard go on TV at the weekend and say millions will die from side-effects?

But I guess the definition of safety in the above chart is different to my definition of safety here. Models won't save us though, everyday is a new model, it's pure shite.
Those models are trash. Estonia x2 as many infected and x5 more dead than in Latvia but somehow they are ahead in safety?
 
Trump's snake oil saved Tom Hanks:
I like how it's framed as a "controversial treatment" and she warns people about using it after it may be what helped her. I have to wonder if any of that would be said if the Trump never mentioned it. What makes it controversial other than the name of the drug coming out of his mouth and some morons swallowing fish tank cleaner?
 
Those models are trash. Estonia x2 as many infected and x5 more dead than in Latvia but somehow they are ahead in safety?

Yeah. Also, the reason I go off on one at these models and label them scaremongering is what is the reader supposed to do about it? Emigrate there? Tomorrow it will change anyway. The gov here (0.27% death rate) have cancelled school till September. Cancelled school final exams for teenagers. So many people are probably going to lose their livelihood as most towns are full of independent shops. And Facebook folks are like praising the government, but days/weeks/historically before this the gov here are one of the most corrupt in Europe. People are sheep.
 
Another example of the bullshit that is flying around proclaiming to be truth.

Anyway, it can't be truth because another apparent reliable source, bnonews.com, places Germany 5th on the danger list with a 2.46% death rate, so how the fuck they're number 2 on the safe list is beyond fearmongering crap.
I didn't see the list from bnonews, but these lists certainly don't just look at death rates.
Death rates are a function of infected and dead. Meaning if you find more infected(by testing more) your death rate will go down. Since testing varies greatly across countries, the national death rates at the moment aren't a reliable metric at all.

But I guess the definition of safety in the above chart is different to my definition of safety here. Models won't save us though, everyday is a new model, it's pure shite.

The list takes into account things like ICUs per capita, beds per capita, doctors per capita and other factors determining how high/low the risk is of not receiving adequate care anymore because the healthcare system is overcapacity.
Because one thing is for sure: When we don't have the capacity to treat patients with everything we got, death rates will definitely skyrocket.

Other factors that played a role in this list where when shutdowns were started, how well the population sticks to the rules, how widespread testing is and how well organized the government response is and how comprehensive and fair the economic and social aid packages are.


But keep in mind that this list is by DKV, an economic ThinkTank based in London specializing in risk management.
They are using available data points to find out which countries will make it through the crisis well and represent save bets for financial investment.


Slovakia making the top 40 is not a bad feat for a rather small and economically insignificant country. Considering that Slovakia surely can't compete with some of the top-ranking nations when it comes to healthcare capacity and economic might, it means that Slovakia must have done basically everything else right.
The US came in 70th btw, despite having one of the highest ICUs per capita in the world and despite being very economically powerful.

The one thing I find strange in this list is Turkey.
Turkey is going to get fucked. They only issued a shutdown order yesterday and with no prior warning, leading to everyone rushing out to panic buy. And they have no further plans. As it stands now the showdown ends in like a day.
The interior minister wanted to resign considering the epic fuck up, but Erdogan asked him to stay. I guess he needs someone to take the fall for him once the shit hits the fan.
 
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Trump playing a 5 minute video at the presser of the media getting everything wrong, and then Governors praising him, was hilarious.

Apparently to the MSM hacks, that was the worst thing to ever happen to our nation, currently. I wonder why that is? :pie_thinking:

I like how it's framed as a "controversial treatment" and she warns people about using it after it may be what helped her. I have to wonder if any of that would be said if the Trump never mentioned it. What makes it controversial other than the name of the drug coming out of his mouth and some morons swallowing fish tank cleaner?

You know the answer to that. Had anyone in the DNC mentioned it... it would be a "miracle cure".
 
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I like how it's framed as a "controversial treatment" and she warns people about using it after it may be what helped her. I have to wonder if any of that would be said if the Trump never mentioned it. What makes it controversial other than the name of the drug coming out of his mouth and some morons swallowing fish tank cleaner?

It's controversial because all around the world some people are pushing for a larger use of it, while others say the risk/reward can't be established from the past studies and we need to wait for the results of ongoing ones.
 
It's controversial because all around the world some people are pushing for a larger use of it, while others say the risk/reward can't be established from the past studies and we need to wait for the results of ongoing ones.

Nah, it's controversial because Trump talked about it. If Obama had, people would be lining up to take it.
 
Swedish hospitals also stopped giving the drug for that reason. Early results from French studies also identified 54 suspicious cases (including 7 deaths) of severe complications due to the drug. But let's make it all about China.



600 mg is the amount recommended by Didier Raoult, the French doctor who's been pushing it and is often said to be the person with the most knowledge of that drug worldwide (being an expert on tropical diseases). Which is why people are cautious with that whole hidroxychloroquine stuff : the way it's used to fight covid-19 isn't the standard posology, nor are patients standard patients.

The south koreans suggest 200 MG x 2 a day.

Also the South Koreans warned about the possible side effects in their protocol. Actually there is an article from feburary with the exact verbage being used here that makes me a bit suspect.

But causing arythema with large doses has been well known since feburary by the south koreans which they warned about.

I will have to check Raoults protocol. I am sure Zev also only suggested 400 MG a day not 600 MG.

Considering that RA and lupus patients take this unless it interacts with COVID in a certain way i have to blame the doctors for this. You can over dose and die feom tyelnol but most people dont. Unless of course you take a dangerous dosage. Again this doesnt mean i think HQ is the cure. But a drug that has been used for decades and by millions of people shouldnt be causing heart problems unless use improperly.

EDIT:

Here is the SK protocol from Feburary


However, if patients are old or have underlying conditions with serious symptoms, physicians should consider an antiviral treatment. If they decide to use the antiviral therapy, they should start the administration as soon as possible, the task force noted.

For the antiviral treatment, the doctors recommended lopinavir 400mg/ritonavir 100mg (Kaletra two tablets, twice a day) or chloroquine 500mg orally per day.

As chloroquine is not available in Korea, doctors could consider hydroxychloroquine 400mg orally per day, they said. There is no evidence that using lopinavir/ritonavir with chloroquine is more effective than monotherapies, they added.

Combining lopinavir/ritonavir with chloroquine or hydroxychloroquine could cause serious arrhythmias and drug interactions due to the increased QT interval, the task force said. Thus, the combination should be administered cautiously, in a very limited case, it emphasized.

The antiviral treatment for the new coronavirus will be most suitable for seven to 10 days. Still, the period could be shortened or extended depending on clinical progress, the doctors said.
 
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