One thought is that the THC in marijuana smoke may selectively kill off old, decrepit lung cells that are the most likely to become cancerous, possibly explaining how some studies show a lower incidence of lung cancer in people who only smoke pot.
While cannabis smoke has been implicated in respiratory dysfunction, including the conversion of respiratory cells to what appears to be a pre-cancerous state [5], it has not been causally linked with tobacco related cancers [6] such as lung, colon or rectal cancers. Recently, Hashibe et al [7] carried out an epidemiological analysis of marijuana smoking and cancer. A connection between marijuana smoking and lung or colorectal cancer was not observed. These conclusions are reinforced by the recent work of Tashkin and coworkers [8] who were unable to demonstrate a cannabis smoke and lung cancer link, despite clearly demonstrating cannabis smoke-induced cellular damage.
Furthermore, compounds found in cannabis have been shown to kill numerous cancer types including: lung cancer [9], breast and prostate [10], leukemia and lymphoma [11], glioma [12], skin cancer [13], and pheochromocytoma [14]. The effects of cannabinoids are complex and sometimes contradicting, often exhibiting biphasic responses. For example, in contrast to the tumor killing properties mentioned above, low doses of THC may stimulate the growth of lung cancer cells in vitro [15].
Smoke from tobacco and cannabis contains many of the same carcinogens and tumor promoters [20,21]. However, cannabis and tobacco have additional pharmacological activities, both receptor-dependent and independent, that result in different biological endpoints. Polycyclic aromatic hydrocarbons found in smoke are pro-carcinogens that are converted to carcinogens by the enzymatic activity of the cytochrome P4501A1 oxidase protein (CYP1A1 gene product). Benzo [a] pyrene is converted to its carcinogenic metabolite diol epoxide, which binds to specific hyper-mutable nucleotide sequences in the K-ras oncogene and p53 tumor suppressor [22]. Recent work by Roth et al. demonstrates that THC treatment of murine hepatoma cells caused a dose dependent increase in CYP1A1 gene transcription, while at the same time directly inhibiting the enzymatic activity of the gene product [23]. Thus, despite potentially higher levels of polycyclic aromatic hydrocarbons found in cannabis smoke compared to tobacco smoke (dependent on what part of the plant is smoked), the THC present in cannabis smoke should exert a protective effect against pro-carcinogens that require activation. In contrast, nicotine activates some CYP1A1 activities, thus potentially increasing the carcinogenic effects of tobacco smoke [24].
Clever way to convince your self harmful gateway drugs aren't that bad for you. Whatever floats your boat I guess,
A nap.Why is marijuana a gateway drug and alcohol isn't? and gateway to what?
A nap.
It’s hard to argue for pot slowing you down when you look at Carl Sagan’s record. Apparently a confirmed and admitted stoner, among his many achievements are a Pulitzer Prize, an Emmy, a best-selling novel, as well as more than 500 science papers and articles. He was a founding member of the Planetary Society, and he won a pipe load of scientific awards. Hardly surprising, he is said to have believed in the validity of stoned insights. I believe in them too, it’s just that Carl’s revolved around the origins of the cosmos, not which bagel store is open at 3 in the morning.
Clever way to convince your self harmful gateway drugs aren't that bad for you. Whatever floats your boat I guess,
most smoke it with tobacco from cigarettes.
most smoke it with tabacco from sigarettes.
put a lab coat on a monkey and you it would be more qualified to be called a "scientist" than some of the morons who ran this study. Additionally I am curious as to where their funding came from.
I don't know how common this is in the US... Europe definitely.
What I don't understand is the anger some people are presenting when people are proposing that marijuana isn't as harmful as commonly believed.
Clever way to convince your self harmful gateway drugs aren't that bad for you. Whatever floats your boat I guess,
I think this applies if you smoke it without tobacco which i don't. I live in Amsterdam and the weed here is so strong you have mix it with tobacco. I smoke it almost everyday. Everything has a bad side after a while. With weed it's that you get lazy and don't want to do things.
Not if you are Carl Sagan.
http://valetudocafe.wordpress.com/2...on-the-planet…-cool-enough-to-admit-it/
You know, I've been really skeptical on this issue for a very long time.
However, about a month ago I decided to once and for all to try to keep a very open mind and look into the other side and genuinely try to understand their point of view.
And if my mind changes on the subject, so be it.
On a recommendation, it was suggested that I watch Discovery Channel's "Weed Wars" as it supposedly shows what the legalization movement is all about.
I caught an episode and, though I am always careful of "Hollywoodization," it seemed to be the real deal and quite a professional business that truly wants to give comfort to sick people through the sales of cannabis.
There was a girl in a wheelchair that genuinely seemed to respond to their medicine for her affliction and, while my initial knee-jerk thought was "placebo-effect," I thought, well even so if that helps her and others like her then why not?
Or perhaps, it REALLY does work for pain for crying out loud.
Then one of their "buyers" gets caught stealing money from the clinic.
Okay, whatever, thieves are everywhere regardless of the circumstances.
But when he was confronted as to why he stole, he says it was to buy vicodin to help with his pain from an accident.
A professional marijuana buyer, with access to all the weed he could ever want, working in a clinic that provides product to people who use it to manage pain, STEALS MONEY TO BUY VICODIN FOR PAIN RELIEF.
That's when I realized that we are all being HAD.
No recollection of that. I disagree with drug and alcohol use but I consider myself very reasonable and understanding when it comes to people's personal freedoms.
I disagree in many ways; if you get lung cancer and then go on welfare it affects everyone.
But I take issue with misinformation and lazy journalism.
See how we've gone from:
"Occasional and low cumulative marijuana use was not associated with adverse effects on pulmonary function."
to
"Smoking marijuana may not harm lungs"
to
"Marijuana doesn't harm lung function"
Look how quickly we've devolved.
Yes I apologize for lack of specificity of what I was replying to and why.
The comments probably came off as a bit trollish.
And yes, metaphors only go so far.
oh come on, pot is incidental to his genius. He had a shitload of knowledge beforehand, which smoking pot helped him think about. It enhances what is already there. That he puts it so generally might be a limitation on his perception of society. For him, it brings insight and clarity of thought. It doesn't affect everyone like that.
Maybe you're not implying that, but I hate it when my irresponsible stoner friends (as opposed to the responsible ones who use it correctly) cite Carl Sagan or somebody else to show that they aren't just sitting on the couch unemployed, but expanding their mind.
oh come on, pot is incidental to his genius. He had a shitload of knowledge beforehand, which smoking pot helped him think about. It enhances what is already there. That he puts it so generally might be a limitation on his perception of society. For him, it brings insight and clarity of thought. It doesn't affect everyone like that.
Maybe you're not implying that, but I hate it when my irresponsible stoner friends (as opposed to the responsible ones who use it correctly) cite Carl Sagan or somebody else to show that they aren't just sitting on the couch unemployed, but expanding their mind.
This is obvious in simple terms of amount of tar ingested per session. Nice to see some longitudinal data.
Absolutely true, smoking anything, any amount, does indeed do harm to your lungs. They are only meant to intake air.
it gives me a headache.
cause people act like idiots when they are high around me. they are so loud and obnoxious.
The anti-drug crowd seems bloated with the notion that decriminalizing recreational drug use would spawn some drugged-out loser culture. Stop kidding yourself, everyone over 16 or so who wants to be on drugs already is.
There are people who are comfortable with altering their state of mind, can handle it no bones about it, and understand the ways in which various substances can enhance their lives; then there are other people who are idiots. That's it.
It's quite a bit like the gun debate, actually: pro-drug folk are saying "Drugs don't fuck up lives, stupid people fuck up their lives."
I wonder how the best California buds compare to Amsterdamn buds...
Magic Flight Box makes thick ass coat of resin stick to your throat. You'll see this same coating on the little glass tube that you inhale with. After using it exclusively for a few days it gives you a worse cough than a joint or bong ever would.
It's a cheap piece of crap vape and you get what you pay for.
There is no argument for marijuana prohibition.
Everyone arguing that it should remain illegal, understand that there are millions of highly intelligent people who think you are a goddamn moron. And they are correct.
Biggest waste of money in the smoking industry. Don't buy this garbage.
Magic Flight Box makes thick ass coat of resin stick to your throat. You'll see this same coating on the little glass tube that you inhale with. After using it exclusively for a few days it gives you a worse cough than a joint or bong ever would.
It's a cheap piece of crap vape and you get what you pay for.
Obvious troll is Obvious.If you smoke marijuana, you will use cocaine. If you use cocaine, you will become a drug addict. Therefore, if you smoke marijuana you will become a drug addict.
Anyone explain to me again why we can't have back our Marijuana Thread? Why not name it "MEDICINAL marijuana thread"? Can't be illegal to talk about prescribed medicine.
You must be the boss of workers who you know take hits during lunch break because with that they can.
Because no that thing is not a waste of money nor is it garbage.