I actually broke my rule and sent two messages today.  Reason being I haven't checked Meet Me Now in over 2 months, and didn't realize there are a few hot girls in there that want to meet me.  I should check that more often... haha.
Anyway, this girl has a REALLY short profile that left me with zero to go on.  Nothing in Interests.   Here's her profile:
"I am a romantic at heart and very honest person. I like to live a healthy life style by eating well and exercising; I am looking for the same in a man.
I am looking for a long term relationship; someone who is honest, responsible, loyal and caring, someone who could also be my best friend."
That was it!  Anyway, I usually like to include a joke in my response.  If not a joke, at least show enthusiasm.  My response was this:
"Hi! I read your profile. You mentioned you're an honest person and are looking for another honest person. I like to think of myself as honest... brutally honest sometimes haha 
I also believe that the strongest relationships are built around the two being best friends too. Having a lover, who is also your best friend, usually seems to end well. At least that's my take...
So what are your goals for the future?
Take care,
XXXX"
So I injected a little humor.  I had to be careful.  I wanted to comment on the best friend part, but didn't want to sound like I'd be OK with being just friends.  So I went with I'll be your lover who is also your best friend.  So I won't be your friend unless I'm fucking you.
Anyway, this girl responded.  Here is her response:
"Hi XXXX,
Thanks for writing 

 my name is XXXX I was born and raise in Lima Peru . I moved to California with my family in 2000.
How about you?
I work in advertising doing accounting but I want to become an art director.
How about you? "
These shortened but targeted first messages typically yield me like a 25% response rate.
Another thing: have a good profile!  Have a pic of yourself doing something adventurous and fun.  And use some Clenexia to get rid of those zits 

  (it actually works)
EDIT - I'll respond to her message tomorrow morning.  Don't want to look desperate.