In a game like monkey Island you could always select how to interact with objects and characters. Do you talk to them, do you look at them, do you try to pick them up etc.but isn't that the beauty of exploration? if people already knew what they were going to get before they press the button or interact with the item, then most people will just ignore a lot of those things, and that level of vagueness lends itself to surprises which players may either regret or get rewarded doing.
When you want to explore, then you just try every option, but if you want Guybrush to act like a real person you can do that as well.
During the scene in Jodies room I didn't want her to pick up the guitar and play some tunes, that isn't what "my character" would do at that moment, I just wanted her to give it quick glance, maybe say "I wish I could play some guitar instead"
Why not just press X to look at Objects and just press O whenever you want to pick it up? This gives me more of a feeling that I'm actually playing the character and gives me more options to keep "acting" during gameplay.