EmpressInYellow
Banned
How was this one any more random and weird than Hotel? Asylum? Murder House?
I think Asylum (which I really like) might still hold the record for sheer randomness. They really threw EVERYTHING at the wall to see what would stick in that season.
Off the top of my head, we had:
General mental asylum horror
Serial killer
Aliens
Nazi medical experiments
Demonic possession
Evil Santa
Body horror
The Angel of Death
And that's leaving aside all of the plot threads and character beats that weren't specifically tied into familiar horror tropes or genre elements.