I haven't checked in on the state of AC lore in a while but iirc the main conceit of the Animus is that it allows you to relive the past lives of your direct genetic ancestors, right? Homosexuals tend to sire offspring... less often, lets say.
Its odd that the game lets you play as a completely gay person who is canonically bi (at best). Why not just make the character straight? Not every game needs to let you be a pansexual lothario, especially when it directly conflicts with established lore.
Though in Odyssey's case, that probably is the one where bi would make the most sense.
Also why the fuck not just make Yasuke+Naoe a thing, if you are presumably playing as one person who is related to both of them.