I share the skepticism of Republicans doing anything right, but I do feel that this is one issue where it's possible to bring some of them around on. It just makes too much economic sense. It fits in with state's rights, it fits in with personal freedoms.
Marijuana legalization works with everything Republicans claim to be. Obviously they're able to make up any shit they want for any policy they want, but I think it's nice to at least give this a try.