I have been melting things with this setup.
DrLush
My Spirit Barrage and Zombie Bahrs are my go-to, both dealing excessive amounts of damage. My Soul Harvest increases my DPS, but also crits 1mil+ when it goes off. Spirit Walk is my "Oh shit!" button, giving me health when I go on the run. Hex is for crowd control and gives my friends a zerg focus, with the target receiving additional damage. And Fetish Army gives me pets that draw attention away from me.
Spirit Vessel is my "Oh, there was bad underneath me?!" get-out-of-jail free card. Rush of Essence gives me lots of mana to play with, after spamming Spirit Barrage it fuels my Zombie Bahrs. And Grave Injustice allows for me to fire off more skills as the huge packs in later Torment levels fall before me.