Oh, I think it took waaaaaay more than 3-5 generations for the Nepalese to get where they are today.
But what will really blow your mind is HOW did they evolve for high altitudes AT ALL? If you believe the story, we all came from some savannah primate that itself came from some more primitive tree primate that came from an even less evolved rodent thing. Why do we have ANY genes that account for high altitude? When were we EVER living up on the tops of mountains, or when was ANY ancestor of ours doing it? So either that capability was latent in our genes, having been acquired by some eons distant mammalian ancestor and just kept around for millions of years and just needed selection to pick the folks with the highest concentration of them or "random" mutation somehow CREATED these genes only when humans decided to walk up to the tops of the mountains instead of hang out in the nice forests and plains around sea level.
This is the point where "Darwinian" evolution and the classic system of long evolution under selective environmental pressure kinda falls flat for me. It implies that some group of humans just kept pushing, generation after generation, to live a little bit higher in the mountains, year after year, to put this constant pressure to select for higher red cell load, better oxygen delivery, and all that. Otherwise why do we have the capability to adjust to elevation AT ALL, unless it was
designed into our DNA? Was it from some sea dwelling mammal ancestor? Did we once live up on mountains? Was the O2 content of the planet once much lower and those adaptions hung around? Living through the ice age pushed folks to live in high, arid, low oxygen environments and those where the ones that lived to come down and give all of us those genes? Because pretty much all humans can adapt to high altitudes, given time, though certainly the Nepalese and others like them do it much better.
Imma gonna go smoke some weed now and think rational thoughts