We'll see how this all works, but while I'm still wary of an "Upgraded" spartan in multiplayer, the idea of an Upgraded spartan taking on co-op missions gets me all hot and botherd. Kind of like Mass Effect 3 with less OMG grind repetition. I think the connection between Spartan ops and "Holo training" is most interesting to me.
I'd still prefer a plotline involving seperate UNSC and or ONI spartan forces duking it out over something though, I think that might have more interesting effects on the singleplayer.
I imagine at some point the Infinity will turn up over requiem and send some Spartan 4's to back you up for some crazy end of game epic fight.
Would tie in the Spartan Ops and the training they are doing, possibly whilst out and about in deep space looking for chief.
If they are looking at all