The Guitar: A PRS Custom 24. The thing pretty much plays itself, it's definitely the nicest guitar I've every laid my hands on. I used to be a big Tele guy but they just don't have the range that I need. I was looking at getting an SG or Les Paul for low end, heavily distorted stuff, but then I came across this beauty. I'm glad I didn't have to go the Gibson route, I really hate playing them (though I know they're great guitars).
The Amp: A Mesa Boogie Mark V Combo. This is hands down the most versatile amp you could possibly spend money on. Want to sound like you're playing a Matchless? Cool. How 'bout a Bogner? Done. The sheer volume of switches, knobs, and sliders on this thing is intimidating. It's not all roses though, the reverb transformer shit the bed, and I've had to resort to a duct-tape solution:
This guy runs through the effect loop channels. It's not perfect, but I play with a whole lotta 'verb, so I can't really afford to be without it for too long.
Speaking of effects:
That should all be relatively self explanatory, the green pedal is an envelope filter and the black pedal is a volume, not a wah. I've really never got the hang of playing with a wah, but I use volume swells all the goddamned time.
Considering that a year ago my setup was a Squire 'Classic Vibe' Tele (which is actually a pretty decent guitar) through a Vox AC15 using a POD X3 Live for effects, I'm extremely happy with where my rig is now!