Buddy Holly's 4th single in 1957 was Peggy Sue. 1+9+5+7=22. 2+2=4.
Now guess what song Buddy released in his 4th year. That's right, Peggy Sue Got Married. The significance of the number 4? That's not for me to say. But the clues are all there.
By the way, the B-side to that last one is "Crying, Waiting, Hoping", just in case you aren't convinced.