My university tuition has a laptop lease built into it, so the laptop pretty well travels to most of my classes with me.
I find that taking notes in Word makes the most sense, even when I have the powerpoints ahead of time. When taking notes in powerpoint, I find that the notes, by themselves, don't have context, and I can't study notes off of a computer screen.
I'm averaging 2000 words a lecture in my Western Civ class, so it serves me well.