I'm not sure if any of these have been posted but
Wytches by Scott Snyder, such an incredible comic. Art work is stunning and the story is amazingly creepy.
Across the globe, century after century, men and women were burned, drowned, hanged, tortured, imprisoned, persecuted, and murdered for witchcraft. None of them were witches. They died protecting a terrible and hidden truth: witches, real witches, are out there. They are ancient, elusive, and deadly creatures that are rarely seen and even more rarely survived.
Divinity by Matt Kindt
At the height of the Cold War, the Soviet Union – determined to win the Space Race at any cost – green lit a dangerously advanced mission. They sent a man farther into the cosmos than anyone has gone before or since. Lost in the stars, he encountered something unknown. Something that…changed him.
Saga by Brian K. Vaughn
Although I feel like this is already way too popular to be included!
The series is heavily influenced by Star Wars, and based on ideas Vaughan conceived both as a child and as a parent. It depicts two lovers from long-warring extraterrestrial races, Alana and Marko, fleeing authorities from both sides of a galactic war as they struggle to care for their newborn daughter, Hazel, who occasionally narrates the series.
The Wicked & The Divine by Kieron Gillen
Every ninety years, twelve gods incarnate as humans. They are loved. They are hated. In two years, they are dead.
The Wake by Snyder & Murphy
When Marine Biologist Lee Archer is approached by the Department of Homeland Security for help with a new threat, she declines, but quickly realizes they won’t take no for an answer. Soon she is plunging to the depths of the Arctic Circle to a secret, underwater oilrig where they’ve discovered something miraculous and terrifying...
EDIT:
Fables by Bill Willingham
Once upon a time, a beautiful princess cared for seven amiable dwarves and waited anxiously for her Prince, so they could live happily ever aft—oh, get real! Ms. White is no kept woman! She dumped that two-timing Prince Charming ages ago. Now she’s trying to avoid her attraction to the Big Bad Wolf. And don’t get her started on how much time she’s wasting bailing out her anarchist sister Rose Red and trying to keep the Three Little Pigs off the picket line. It’s all in a day’s work since she became Mayor of Fabletown…
American Vampire Scott Snyder & Rafael Albuquerque
Chronicling the history of a new breed of vampire, American Vampire is a fresh look at an old monster, a generational epic showcasing the bloodlust that lay hidden beneath America’s most distinctive eras.
Like most good stories, it all starts with a question: What if vampires, like all species, evolved? What if, occasionally across generations, a vampire bites someone and creates a new kind of creature—a vampire that takes its strengths and weaknesses—not just from its predecessors, but its environment. So when crusty old Europeans come to the American Old West and turn a thoroughly corrupt gunslinger named Skinner Sweet into even more of a monster, he becomes something entirely new: a new breed of vampire immune to sunlight, one that hates every last one of his aristocratic European ancestors.
Again, kind of popular so not really sure if it counts.
Postal by Matt Hawkins (haven't gotten around tor eading this but really want to)
The townsfolk of Eden, Wyoming wake up to the first official murder the town has seen in 25 years. Their reaction to this isn’t normal, and there’s a reason for that. Eden operates as a haven for fugitive criminals who remain here while new identities, often including facial reconstruction, are created for them. There is zero tolerance for any illegal activity that might draw attention to the town and an “official murder” is the last thing they want. A single, tight-knit family runs Eden with the youngest oddball son Mark Shiffron overseeing the postal branch, the only means of shipping in or out of the city. THE FBI has repeatedly been foiled trying to insert an undercover here; they see Mark as the weak link to exploit. This murder gives them a new opportunity.
The Surface by Ales Kot (hasn't come out yet, but looking forward to it!)
What would happen if Moebius and District 9 had a baby? Maybe THE SURFACE! Welcome to Africa. Ebola is no longer a problem. The West and the East are moving in—and three hacker lovers are searching Tanzania for the place that can change everything: THE SURFACE!
Nameless by Grant Morrison (again, haven't gotten around to starting it, but heard it's good)
An astronomer kills his family, then himself, leaving a cryptic warning. A Veiled Lady hunts her victims through human nightmares. An occult hustler known only as 'Nameless' is recruited by a consortium of billionaire futurists for a desperate mission. And the malevolent asteroid Xibalba spins closer on a collision course with Earth. But nothing is what it seems—a terrifying inhuman experiment is about to begin. Abandon all hope and experience ultimate horror in NAMELESS.