An animated series wouldn't necessarily be as good unless Ian Flynn is writing it, and the guy has his hands full writing multiple comic series as it is. But I'd love to see it.
To be perfectly honest, what I really want is for Capcom to try the Maverick Hunter X experiment again, except as an episodic series, with more of a focus on grounded sci-fi, and a greater effort to flesh out the setting and provide a greater focus on the human element to the setting (humans are mentioned a lot, and yet we haven't seen a living human in the series since Dr. Cain, and Maverick Hunter X killed him off before he was even supposed to appear). I also would like to see a setting that feels more like a true evolution of present society and technology.
Also, I think a new series would probably force the questions of 'what happened between Classic and X series' into the forefront and actually answer them, because the question not actually being answered is becoming increasingly unbelievable, in my book. I mean, the laboratory of the father of robotics actually needing to be re-discovered by a bloody archaeologist of all people? Reploids not being developed by actual robotics experts? Dr. Light not entrusting his work to someone he can absolutely trust (such as Dr. Cossack)? That just breaks all suspension of disbelief for me.
And the actual link between Classic and X doesn't need to be bleak, either - just look at Batman Beyond for a similar presence but keeps established, older characters, changed by circumstances and the passage of time, and lessons that the current protagonist learns from. I can see Rock retiring after Wily finally dies, getting sick of fighting humanity's battles for them, with him and Roll having 'older' bodies that reflect their actual age and experience. Kalinka could perhaps have followed her father's footsteps, and gotten married with kids of her own. Also, there'd probably be a lot of other changes that could very well make the possibility of the Zero, ZX and Legends series occurring in that timeline near-impossible, but it's not like they couldn't reuse characters and concepts from those over the long term - for example, X might quit the Hunters and try to create a new nation, Neo Arcadia, as an experiment to put humans and reploids on equal footing and understanding, but the pressures of governance cause numerous issues, including conflicts with the Hunters when X starts making decisions that get dangerously close to the line.
Yeah, I have so many ideas for an X reboot in 3D. But it would be nothing like the Maverick Hunter FPS project.