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mRNA vaccines will be available for flu, malaria, HIV, and cancer

Buggy Loop

Gold Member
FUCK YEA

Bring on scientific breakthroughs against cancer, any will do.

My mother fought 12 fucking years, 3 different cancers until the last one did one of the worst possible ending in suffering you can imagine doing to an human that i would not even wish to my worst enemy.

Fuck cancer

Fuck brainlets who think they have figured it out that this is all some conspiracy. You look like this :

150-1506304_brainlet-memes.png
 
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Mistake

Member
FUCK YEA

Bring on scientific breakthroughs against cancer, any will do.

My mother fought 12 fucking years, 3 different cancers until the last one did one of the worst possible ending in suffering you can imagine doing to an human that i would not even wish to my worst enemy.

Fuck cancer

Fuck brainlets who think they have figured it out that this is all some conspiracy. You look like this :

150-1506304_brainlet-memes.png
I’m sorry to hear that about your mom. I recently had a cancer scare which I’m currently treating. Scary stuff
 
Imagining a future when people can smoke without fear of cancer, and therefore tobacco companies will advertise en masse but still can’t make health claims.

“It’s toasted.”
The restaurant smells like shit. Either get rid of it or most people won't go there. Free market of the many.
 

Dural

Member
My wife's grandma (she was more like a mom to her) died 3 weeks after receiving the Moderna COVID vaccine at a nursing home. She developed a condition where her body wasn't replenishing her blood platelets. She started bruising all over and had sores in her mouth, was taken to the emergency room a week after getting the vaccine. She was then rushed to Madison and was given a blood transfusion. After the blood transfusion she perked up immediately and was back to her self but within a couple days she needed a transfusion again. The hospital talked to my wife's family saying she would constantly need blood transfusions to live and they decided to let it run it's course. She was moved to a nursing home and died 5 days later. My wife talked to the New York Times as they had a reporter that was writing an article about this reaction to the vaccine. They say there haven't been very many cases of it, but having witnessed this first hand I likely won't be getting it and my wife definitely won't.

 

Soodanim

Gold Member
My wife's grandma (she was more like a mom to her) died 3 weeks after receiving the Moderna COVID vaccine at a nursing home. She developed a condition where her body wasn't replenishing her blood platelets. She started bruising all over and had sores in her mouth, was taken to the emergency room a week after getting the vaccine. She was then rushed to Madison and was given a blood transfusion. After the blood transfusion she perked up immediately and was back to her self but within a couple days she needed a transfusion again. The hospital talked to my wife's family saying she would constantly need blood transfusions to live and they decided to let it run it's course. She was moved to a nursing home and died 5 days later. My wife talked to the New York Times as they had a reporter that was writing an article about this reaction to the vaccine. They say there haven't been very many cases of it, but having witnessed this first hand I likely won't be getting it and my wife definitely won't.

That’s awful luck, sorry to hear it. I imagine all the reassurance and statistics in the world won’t make much of a difference to what’s essentially a first hand witness account like that, so I can understand why you wouldn’t want to take it.
 

llien

Banned
“I worry about innovation at the expense of practicality,” Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine and an authority on vaccines, said recently. The U.S. government’s Operation Warp Speed program, which has underwritten the development of Moderna’s vaccine and pledged to buy Pfizer’s vaccine if it works, is “weighted toward technology platforms that have never made it to licensure before.”

Cancer vaccine started where? America under Trump.
Trump deserves a lot of credit for dumping billion into "we have never seen that shit work" developments of mRNA vaccines indeed, but note that BioNTech is a German company (that collaborates with Pfizer on production/distribution)
 

llien

Banned
4. This is a very complicated situation and the lack of transparency makes it difficult to trust information, especially when the information providers themselves are turning valid concerns into mockery and/or treating it as political manifestation that needs to be suppressed. And it's not, it's just cautious consideration.


Look at this forum. The ad sense rules changed and suddenly we can't talk about certain things. Our dear EviLore EviLore changed the rules as soon as the cash flow did. Kind of funny, isn't it? Hey, I understand, I have a family to provide to as well, but come on, are we here to lick the media and Google's balls now? We cannot deviate from what they deem to be the right path?

Covid passports are being discussed when they said they'd never allow it. Effectiveness of different vaccines is being put under the carpet... what else isn't what they claim to be? What else they decide the public shouldn't know? Which other decisions should be taken out of the individual hands and forced upon them?

So as soon as the media says Oceania is fighting Eurasia instead of Eastasia are we supposed to accept? "Hey we claimed the vaccines were all the same but now they're not and don't question it". How about no?

Shouldn't I (and we, here) be able to have discussions instead of receiving cheap sarcasm from the "Lord" himself? Because it seems like passive aggressive silencing, you know... Are you cockroaches too afraid to lose your accounts so you suck his dick instead? Hmm, I can't get behind that...
I wish people would not be banned from this forum for unpopular opinions.
Popular speech not needing protection and all.
 

Ichabod

Banned
The most interesting takeaway for me is this tech being shown for what it really is. If the same tech being used against Covid is able to functionally transition to combating something that isn't a virus (i.e. cancer), it's more akin to gene therapy than a "vaccine."
 

AnAnole

Member
The most interesting takeaway for me is this tech being shown for what it really is. If the same tech being used against Covid is able to functionally transition to combating something that isn't a virus (i.e. cancer), it's more akin to gene therapy than a "vaccine."
It's a vaccine, you idiot. It's a method for showing your immune system the antigen so that it can produce the necessary antibodies to ward off future infection from pathogens with similar antigens.
 

manfestival

Member
Does this mean I can go around raw dogging knowing I can take the mrna to vaccinate myself from any STD? If so, count me in!
 

BlueAlpaca

Member
There are hundreds of cancers, will it be just one vaccine to prevent all or most cancers? I doubt it. Maybe for survivors to ensure it doesn't return. Either way this technology sounds great.

The breakthrough I'm waiting for is new (and large) penis construction via stem cells. Take sample from patient, grow the little beast in a lab, cut off the old one and install new. They actually did this with rabbits I think. Honestly you can laugh about it but that would change the world.
 

SF Kosmo

Banned
I want more long term data because I'm weary about any treatment that relies on an autoimmune response,
Bad way to look at it. You could argue that the response is autoimmune in the short term because it's hijacking cells to make the proteins, but it gets used up. Your body doesn't go in doing that. In the end it works like any vaccine, using your body's own immune response to recognize and attack a harmless substitute for the virus with compatible antibodies.


By the way, Moderna and NovaVax have both announced they will be combining their new flu and Covid vaccines into a single annual shot you can get. The latter isn't mRNA based, it uses lab-grown proteins so maybe you'll prefer that?
 

SF Kosmo

Banned
There are hundreds of cancers, will it be just one vaccine to prevent all or most cancers?
No definitely not. It'll be teaching your body to recognize specific types of cancer so your immune system can attack it.

Unlike viral vaccines it's also the sort of thing that might work after you already have cancer as a cure/treatment. I don't know about these mRNA ones in particular but there's some really interesting research out there on this sort of treatment. There have been patients who has really advanced cancer that made full comebacks.
 
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Irobot82

Member
No definitely not. It'll be teaching your body to recognize specific types of cancer so your immune system can attack it.

Unlike viral vaccines it's also the sort of thing that might work after you already have cancer as a cure/treatment. I don't know about these mRNA ones in particular but there's some really interesting research out there on this sort of treatment. There have been patients who has really advanced cancer that made full comebacks.

I didn't know the body could fight cancer, I thought that was part of the problem. This sounds like really neat stufff.
 

jonnyp

Member


Good vid that gives a background on mRNA vaccines and how they’ll be used to treat all manner of diseases now that they’ve proven themselves in a big way during this pandemic. Cancer vaccines are currently in phase 2 trials and are 2-3 years out.

Feels like we’re going to hit the ground running technologically when we get past this pandemic.


This is of course fantastic but we need a solution to fight bacteria or else we are fucked anyways.
 
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SF Kosmo

Banned
The most interesting takeaway for me is this tech being shown for what it really is. If the same tech being used against Covid is able to functionally transition to combating something that isn't a virus (i.e. cancer), it's more akin to gene therapy than a "vaccine."
No it's not gene fucking therapy, it's very much a vaccine. And there are actually adenovirus-based cancer therapeutics in development as well.

Vaccines are something you take that provokes you body's immune system to recognize and attack an infection using your body's natural immune system.

The thing that makes cancer deadly is that your body can't tell the cancer cells from your healthy cells, so your body doesn't fight them. But if your train your body to recognize a cancer cell, then your immune system can do it's thing and kill it.

You can do that with mRNA or with a messenger virus or whatever but these treatments have been shown to completely cure patients who didn't respond to any other treatment. Like 100% cancer free.
 

SF Kosmo

Banned
I didn't know the body could fight cancer, I thought that was part of the problem. This sounds like really neat stufff.
Yeah your exactly right, you body doesn't normally. The ones I read about worked by essentially "tagging" the cancer cells so your body could recognize and attack them. I imagine mRNA would work similarly but I haven't actually read up on those.
 

Irobot82

Member
Yeah your exactly right, you body doesn't normally. The ones I read about worked by essentially "tagging" the cancer cells so your body could recognize and attack them. I imagine mRNA would work similarly but I haven't actually read up on those.

I understand (kinda) the viruses. It's like a lock and key sorta thing. I just don't understand how they can move that to cancer. But it's super cool if it works. I think we're going to starting seeing some crazy shit between mRNA and CRISPR in the next 20 years.
 

Ichabod

Banned
Well the vaccine trains your body to treat it as one and use your immune system to attack the cancer cells and clear it. Splitting hairs, aren't we?

I'd say it's a significant distinction. A vaccine, by definition, uses a weakened virus to stimulate a cellular immune response to combat viruses, in a sense enhancing a process that your body does straight out of the box. Whereas, MRNA therapy has to alter baseline cell function to "train" it to attack a non-virus thereby forcing the immune system to do something outside of normal operating parameters. Seems pretty apples to oranges to me.
 

SF Kosmo

Banned
I'd say it's a significant distinction. A vaccine, by definition, uses a weakened virus to stimulate a cellular immune response to combat viruses, in a sense enhancing a process that your body does straight out of the box. Whereas, MRNA therapy has to alter baseline cell function to "train" it to attack a non-virus thereby forcing the immune system to do something outside of normal operating parameters. Seems pretty apples to oranges to me.
That's not exactly true though.

1) Vaccines don't have to be a virus, they just have to be something your body thinks is a virus (for example NovaVax uses protein nanoparticles that mimic Covid, but has no virus) It's a training dummy that your body's natural immune system clears, and which provokes antibodies that are also able to fight the disease.

2) But that's the same principle behind mRNA vaccines too, just with an extra step. Your characterization here is not correct. It doesn't train your cells to attack anything it actually just hijacks some cells to produce proteins and the proteins are the vaccine. But just like with a traditional vaccine, it's your body's natural response to clearing those proteins that gives you the immunity.

If you really want to split hairs, it's like precursor that causes your body to create the vaccine, but the way it works from then on is exactly the same.
 
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Cancer vaccines?

Why does that sound too good to be true?
You're not wrong to be sceptical, we all should be. That being said I grew up with the 'Inspector Gadget' cartoon where a kid in the 90's had access to a fantastical mobile computer a fraction of the power of a smartphone that was the size of a textbook.

Of course we should wait for results, but the company that cures cancer will be richer than God forever. There is more than enough financial incentive to overcome any level of cynicism.
 

Ichabod

Banned
Your characterization here is not correct. It doesn't train your cells to attack anything it actually just hijacks some cells to produce proteins and the proteins are the vaccine.

It's not my characterization, though.

Well the vaccine trains your body to treat it as one and use your immune system to attack the cancer cells and clear it.

And, again:
vac·cine (văk-sēn′, văk′sēn′)
n.
1.
a. A preparation of a weakened or killed pathogen, such as a bacterium or virus, or of a portion of the pathogen's structure, that is administered to prevent or treat infection by the pathogen and that functions by stimulating the production of an immune response.

-American heritage dictionary

I'm not seeing anything that includes pathogen mimicking nanoparticles or treating anything outside of viruses. MRNA therapy simply does not mesh with the textbook definition of a vaccine and trying to characterize it as one is disingenuous.
 

SF Kosmo

Banned
It's not my characterization, though.



And, again:
vac·cine (văk-sēn′, văk′sēn′)
n.
1.
a. A preparation of a weakened or killed pathogen, such as a bacterium or virus, or of a portion of the pathogen's structure, that is administered to prevent or treat infection by the pathogen and that functions by stimulating the production of an immune response.

-American heritage dictionary

I'm not seeing anything that includes pathogen mimicking nanoparticles or treating anything outside of viruses. MRNA therapy simply does not mesh with the textbook definition of a vaccine and trying to characterize it as one is disingenuous.
Do you think that if you bold the one part I can't read the "or a portion of a pathogen's structure" part immediately after it, dude? What even is your argument? The dictionary just affirmed what I said.

The mRNA vaccines have an extra step, in that they use your cells to generate those spike proteins (the "portion of the pathogen's structure") rather than giving them to you directly (as in the protein adjuvant vaccines) but it's still your body reacting to those spike proteins that creates the immunity just like any vaccine.
 
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FunkMiller

Banned
Mods - any chance I can be allowed to post in the coronavirus thread again? I'm still blocked, despite being told it'd only be for a couple of weeks! Have emailed you, but had no response. I promise I'll be good!

(sorry for the hijack gang, as you were)
 

Ichabod

Banned
Do you think that if you bold the one part I can't read the "or a portion of a pathogen's structure" part immediately after it, dude? What even is your argument? The dictionary just affirmed what I said.

The mRNA vaccines have an extra step, in that they use your cells to generate those spike proteins (the "portion of the pathogen's structure") rather than giving them to you directly (as in the protein adjuvant vaccines) but it's still your body reacting to those spike proteins that creates the immunity just like any vaccine.

Incorrect. If the proteins are not derived from the actual, naturally occurring pathogen or a piece (read: portion) of it, you do not have, by definition, a vaccine but something else. The end result may be immunity (which the Covid vaccine doesn't provide, by the way) but the means to get there are different enough to warrant distinction. But don't take my word for it:

...any active pharmaceutical ingredient, which contains or consists of a recombinant nucleic acid, used in or administered to human beings, falls under the scope of the regulation for advanced therapy medicinal products [6]. Therefore, mRNA-based therapeutics are categorized as gene therapy.

Excerpt from the article
-The National Center for Biotechnology Information

But this is all beside the point, cancer is not a pathogen. Vaccines are for preventing pathogens. Why are we calling this type of treatment a vaccine when there is no pathogen involvement? It's a misnomer.
 
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