Support NeoGAF

[Spyxos]

Glados (Portal 1-2)
Illusive Man (Mass Effect 2)
Handsome Jack ( Borderlands 2)
Joker (Batman Arkham Asylum)
Sephiroth (Final Fantasy 7)
Psycho Mantis (Metal Gear Solid)
Dutch Van Der Linde, Micah (Red Dead Redemption 2)

 

[MasterCornholio]

Not a major villain but I loved fighting him. Crazy fat man on roller skates planting bombs like crazy. Then there's this guy.

 

[The Lunch Legend]

Dickson
Krelian
Grahf
Lavos
Sephiroth

 

[ungalo]

The usual stuff

The Patriots
Gaunter
Dutch
John Konrad
Maria
Caesar
Andrew Ryan
SHODAN
Gwyn
Handsome Jack
Illusive Man
Glados and Wheatley
The Jackal
Kreia
Wesker
and others

 

[JohnSpartanLee]

Dracula
Kefka
Sephiroth
Wesker

 

[Art The Clown]

Kefka
Gwen

 

[Koppelthorn]

Big Boss is a very well written villain I think

 

[kunonabi]

Much harder list for me to figure out

Final Fantasy IV - Golbez
Final Fantasy VI - Kefka
Mega Man Legends - Tron Bonne
Castlevania - Dracula
The Legend of Zelda - Ganon
Silent Hill 3 - Claudia Wolf
Clock Tower - Scissorman
Resident Evil 3 Nemesis - Nemesis
Resident Evil Outbreak - Greg Mueller
Silent Hill - Dahlia Gillespie
Shenmue - Lan Di
Metal Gear Solid - Big Boss

 

[Fuz]

Sephiroth
LeChuck (Monkey 1-2)
Gaunter O'Dimm
Handsome Jack
Me

 

[Abriael_GN]

Lisa Khan and Sarah Cardell

 

[L*][*N*K]

Liquid Snake, illusive Man, Ganon (Ocarina of Time), Handsome Jack

 

[DemonGamerTTT]

Sigma - Megaman X

That bastard gave me a lot of trouble at the time.... He's also very mysterious and powerful.

 

[Captain Toad]

Um.....

Where are all the votes for Waluigi??

 

[F31 Leopard]

Albert Wesker
M.Bison
Liquid Snake
Jetstream Sam
Senator Armstrong
Dr. Wily
Geese Howard
Kefka
Ultros
Lan Di
Traitor Jackknife (Tokyo Xtreme Racer)
Devil and Angel (Ridge Racer)

 

[T4keD0wN]

Are Kerrigan and Vergil bad guys?
If not Frank Fontaine.

 

[Spyxos]

Are Kerrigan and Vergil bad guys?
If not Frank Fontaine.

These are short term villains.

 

[begotten]

1. Kain
2. Revolver Ocelot
3. Frank Fontaine
4. Kefka
5. Dracula

 

[Skull-Knight]

Gaunter o'Dimm
Gaunter o'Dimm
Gaunter o'Dimm
Zeus

 

[PanzerCute]

The vilain from Deadly Premonition.

 

[CatLady]

LOVE the grunts. Sometimes I hate to kill them they're so funny.
Of course, one of my all-time favorite actors, Lance Reddick as Martin Hatch

As others already mentioned:
Frank Fountaine - Awesome and the illusive Man, Martin Sheen makes a great villian.

 

[TrueLegend]

Dante....the best.

 

[Nankatsu]

Jin Kuwana
Daisaku Kuze
Akira Nishikiyama
Sephiroth
Albert Wesker

 

[Fuz]

Gaunter o'Dimm
Gaunter o'Dimm
Gaunter o'Dimm

Fuck me, how can I forget him?
Added.

 

[Ulysses 31]

Bayonetta

Rodin

 

[SeraphJan]

Kratos

This

Not this

 

[Torrent of Pork]

 

[GametimeUK]

My favourite antagonist is the CMA.

 

[Husky]

Mr. Scratch and The Dark Presence (pictured in the form of Barbara Jagger) from Alan Wake

Vaas Montenegro, from the hit game Assassin's Creed, and the Brethren Moon over Tau Volantis from the Dead Space series

 

[SeraphJan]

Vaas Montenegro

 

[Lokaum D+]

Zero - MMX
Cole - Infamous 2
Radek - Killzone 2
Dante - DMC
Lady D - RE8
OG Kratos - GoW 1 2 3

 

[Furozen]

 

[NanaMiku]

Pixy

 

[TheInfamousKira]

Kojima/Hasan
Konami
Nomura

Edit: read the op wrong, change my answer to Troy Baker.

 

[as1m]

Bob Page

 

[Labolas]

 

[Mozzarella]

I will definitely forget some.

Albert Wesker (Resident Evil)
Glados (Portal)
Andrew Ryan (Bioshock)
Dutch Van Der Linde (RDR2)
Gaunter Odimm (Witcher 3: Hearts of Stone)
Luca Blight (Suikoden II)
Shodan (System Shock 2)
Psycho Mantis (Metal Gear Solid)
Sephiroth (Final Fantasy VII)
Shao Khan (Mortal Kombat 2)
Kerrigan (Starcraft)
Senator Armstrong (Metal Gear Rising: Revengeance)
Arthas (Warcraft 3)
Letho (Witcher 2)

 

[Danjin44]

Not in order...

Caim

Zero

Nier

9S

 

[Rush2112]

J Alan Bragg
Bobby kotik
Yves Guillemot

 

[DKPOWPOW]