What.
I'm sorry guys, but Nathan Fillion being casted for the role of Drake is although the best choice, but it is
realistically impossible.
For that to happen, the original Uncharted needed to come out in 2004 and be a smashing hit by the time the sequel happens in 2006 or 2007.
Point in case:
1) Uncharted 1 came out in 2007. This is Nathan Fillion in 2007:
The original Uncharted was nowhere near the huge franchise of a game with a pedigree behind it as it is today, so no movie would be made then - realistically speaking.
This is, the best, and only time, in which Nathan Fillion would have fit the role as in later years, he didn't age well for the role.
Moving on.
2) Uncharted 2 came out in 2009. This is Nathan Fillion in 2009:
This is the turning point where the franchise truly broke new ground and acquired all the accolades that has now firmly placed ND into a respective studio. But, a second game in a franchise is almost ever hardly turned into a video game during a time where the trend of turning movies into video games were at it's peak.
At this rate, Nathan Fillion has aged just a little and we can see him slowly become less leaner. Not a big deal as any production with money can put their actors for training before a movie. Not ideal, but workable.
Moving on.
3) Uncharted 3 came out in 2011. This is Nathan Fillion in 2011:
Uncharted 3 was probably where the franchise was at it's height in terms of brand and marketing power. This in itself is reflected by how ridiculously bombastic the third entry in the franchise is, which unfortunately tarnished the story end of things in the game. But, the popularity was definitely at it's peak and the time where a talk about a movie can be seriously had (but not really).
Unfortunately, Nathan Fillion at this time has become a far more relaxed man and it shows. Making this particular time and year to be the worst time to cast him as
Nathan Drake as originally portrayed in the original trilogy.
TL/DR:
Not to say it wouldn't work, but his star power had waned by the time any serious talk of a film ever got off the ground after franchise gained huge success in later entries, and he wasn't at his prime at the time those talks started.
No one was going to do a Marvel and hire an actor with no huge star power for a video game movie with likely a huge budget at the time.
At least we got this fan film: