I'm on OKC, and I'd say it has been overall pretty good so far. I've been on about 20 dates since I've joined, and I've actually ended up sleeping with 6 of them, though not all on the first date. Whoever mentioned that the site caters to the hook-up crowd definitely seems to be right.
Of course, I do send out many messages and most do not get replies. Also many women will read my message, look at my profile, and still not reply. It's normal. I get about 35-40 visitors a week, though I probably checked out half of them first.
The guy who said don't post pics at your computer is right. Pictures doing something fun, or with people are best, so it looks like you're a fun person to be around. Also, don't list Pokemon, video games, or things that most people deem to be nerdy, unless you only want a girl likes those things too.
When messaging a girl I try to think of what everyone else probably says, and try to be unique. I guarantee every girl gets messages about the music or movies she likes, with guys saying they like it too. She doesn't care, and it's not going to get you anywhere. Find a detail in her name, in her summary, anything you think most people won't notice, and just make a one liner about it. It usually works.
I see people say to get a phone number as soon as you can. Be careful. Ask too early, and the girl will get scared. However, too many "how was your night" messages, and back and forth conversations are stupid. In the second message ask where they live in the city. Third message suggest meeting up for a drink. The number follows naturally.
It all comes down to how often you use the site. If I am not active, I hardly get any visits or messages. You have to be diligent, and just keep trying.