I'm not talking nationally, just locally. There's a multitude of reasons like this in many states, but I think this could have been a factor here. Not saying she'd have won if this worked out, but the strike played into the hands of what rural pennsyltucky republicans have been saying about Philly for so long that it seems significant to me.
I agree that the SEPTA strike didn't help. Any animosity that people had towards overpaid unionized workers striking to make more money was certainly put on display right up to election day.
Agree that there were also a large number of very carefully crafted local efforts to win different local regions individually.