I have never played any PC game on my Mac (natively or through VMware Fusion) so I don't really know about performances and such. I completely forgotten about Boot Camp. I could try it. I have played PlayStation 1 games on PCSXR and it runs fine but it means nothing for this game.
There's a free RE6 Benchmark you can download and try, but ironically it's not very representative of the game (more of a stress test with way, way more enemies on screen than you would ever see in the actual game). If that tells you the game would run properly, or you can stomach the performance you see there, you should be fine. :]