So I played through the GD:RB demo again after my wife left for work and I could crank it up and the calibration still feels off. I played RB2/Beatles with 0 Video / 30 Audio for my receiver, and it's just about perfect. Did the same thing on GD (and even tried 0/0 because I ran with that for almost a year), and still ended up missing silly stuff.
I even tried two different guitars, thinking maybe one of them was fritzing out, and had the same problem. Popped in RB2 and everything's fine. I'm only missing things I actually missed. Hopefully I can find some good numbers for GD:RB or else I'm gonna get pissed.