I just finished a play through of this on Switch 2, so in case anyone is interested.
I was playing from a physical switch 1 card btw and mostly docked.
1. I did get crashes and had to redo sections here and there. They started about mid way through the game, and were occasional either while driving or during QTE sections usually. Later in the game during one of the QTE sections I was getting a repeating crash. I did that part handheld and got past it. Could be coincidence, or the reduced handheld res changed something. But for the most part with crashes, just redoing got me past them without much lost time.
2. Driving controls are messed up - extremely sensitive probably because of the higher FPS. Go slowly!
3. Sounds are still a problem - sometimes gunshot sounds and footsteps were muted, no car sounds or siren sometimes. This issue was there in S1 so it wasn't just a memory problem.
4. For the most part framerate is good now. There is some slow down when driving in the city, but nothing like as bad as Switch 1.
So it's a better experience on Switch 2 - playable even - but still has some problems on top of the jank that was in the game already.
But if you're curious about it, this is a reasonable way to experience the game.