If they outright repeal it, they will destroy themselves as too many (20+ million) voting Americans will be negatively impacted immediately and the knock-on effects will be felt through the entire health industry, including old republican voters who want their meds and medicare.
They won't do this.
They will grandstand for a while (probably a long while, especially if obstruction is left open and the filibuster isn't attacked immediately), tear it apart little by little, but they won't outright tear it down unless they are insane and want to immediately start dismantling themselves. They will also use it as an blame-space against ever-rising premiums (as its not going to stop), and scapegoat on Obama for years further.
If the filibuster isn't addressed Day-1, then what little sanity remains will gridlock government for four years.