Speaking to the BBC, she characterises the technology as a "slippery slope" and "a betrayal" that "goes against everything humanity is based on".
Her attention was focused on the software last year, after meeting a young songwriter who'd been employing it in her work.
Frustrated that male artists wouldn't listen to her demos, Crow's acquaintance paid to have an AI clone of singer-songwriter John Mayer replace her vocals.
When Crow heard the song, she was so "terrified" that she was "literally hyperventilating".
"I know John and I know the nuances of his voice," she says. "And there would be no way you'd have been able to tell that he was not singing that song."
Her horror deepened when Drake used AI to resurrect the voice of late rapper Tupac Shakur on his song Taylor Made Freestyle earlier this year.
The track was
subsequently removed after lawyers from Tupac's estate threatened to sue, but Crow says it should never have been released in the first place.
"You cannot bring people back from the dead and believe that they would stand for that," she protests.
"I'm sure Drake thought, 'Yeah, I shouldn't do it, but I'll say sorry later'. But it's already done, and people will find it even if he takes it down.
"It's hateful. It is antithetical to the life force that exists in all of us.
www.bbc.com
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