Um...I just went withfor my 2nd playthrough so I can't speak for that, but my experience in the 3rd and subsequent was thatMikami.any subsequent interaction will be missed if you choose the first response when first bumping into him
For me, it was the second response that locked me into the route: "It was a present." Asking, "Do you know him?" or whatever the first option was let you stay off the path. I accidentally locked into his route, hence why I did it second.