I tried Prime 1 about 10 years ago and thought the GameCube controls were absolutely atrocious, outdated and unintuitive. Dropped it after a few hours. Then I found the Wii Trilogy version for dirt cheap (€10!) and tried it again, and while the controls were much more intuitively, it also made me nauseous because of motion sickness. Dropped it again after an hour or two.
It took me until Prime 1 Remastered to actually appreciate it. Most of the time I enjoyed it tremendously, but in my opinion it was kinda held back by the late-game artifact hunt which fucked the pacing, and the last sequence until the final boss. It's such a shame Prime 2 and 3 aren't available on Switch, because I'd have loved to play through them before getting 4.
And to finally answer your question: yes, Prime 4 does interest me and I plan on getting it day one (on Switch 1). Even though I still prefer the 2D Metroid series, with Super and Dread as my favorite.